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Health Problems of Civilization
eISSN: 2354-0265
ISSN: 2353-6942
Health Problems of Civilization Physical activity: diseases and issues recognized by the WHO
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4/2022
vol. 16
 
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DISEASES AND PROBLEMS DISTINGUISHED BY WHO AND FAO
abstract:
Original paper

LIFE EXPECTANCY IN PATIENTS WITH STAGE III A NON-SMALL CELL LUNG CANCER (NSCLC) TREATED WITH NEOADJUVANT CHEMORADIOTHERAPY (NCRT), NEOADJUVANT CHEMOTHERAPY (NCT), NEOADJUVANT CHEMOTHERAPY + ADJUVANT RADIATION THERAPY (NCT + ADJUVANT RT)

Katerina Maliarchuk
1
,
Andrey Ganul
2
,
Bogdan Borisyuk
2
,
Leonid Bororov
2
,
Anatoly Shevchenko
2
,
Vladimir Sovenko
2
,
Lubov Kutsenko
3

  1. Department of Oncology, the Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
  2. Department of Chest and Mediastinal, National Cancer Institute, Kyiv, Ukraine
  3. Department of Statistics, National Cancer Institute, Kyiv, Ukraine
Health Prob Civil. 2022; 16(4): 302-311
DOI: https://doi.org/10.5114/hpc.2022.121417
Online publish date: 2022/12/30
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Background
This work is а comparative study of survival in patients with stage III A non-small cell lung cancer (NSCLC) treated with neoadjuvant chemoradiotherapy (NCRT), neoadjuvant chemotherapy (NCT) and neoadjuvant chemotherapy and adjuvant radiation therapy (NCT + adjuvant RT).

Material and methods
Three groups of 65 people were selected. The first group received NCT, the second group – NCT, and the third group – NCT + adjuvant radiation therapy. The NCRT group received radiation therapy of 30 Gy. Survival was assessed using the Kaplan and Mayer scale and according to the log rank criteria.

Results
The statistical criterion for NCRT in relation to NCT was -3.51279, r=0.00044. The statistical criterion for NCRT in relation to NCT + adjuvant RT was -2.88568, r=0.00391. Less reliable dependence was observed between NCT and NCT + adjuvant RT (the statistical criterion =1.809508, p=0.070307).

Conclusions
Performing NCT, NCRT or NCT + RT and the status of complete morphological response (CMR) during the revision of histological material, it is possible to predict survival for a period of up to 36 months. NCRT is the optimal method of treatment.

keywords:

neoadjuvant therapy, pneumonectomy, lobectomy, non-small cell lung cancer, overall survival

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