Introduction

Psoriasis is a chronic inflammatory skin disease with immunologic etiology.

Aim

To investigate the levels of the proinflammatory cytokines tumor necrosis factor  (TNF-), interleukin 23 (IL-23) and IL-17 in patients with psoriasis and psoriatic arthritis with concomitant metabolic syndrome.

Material and methods

This study included 60 patients with severe psoriasis.

Results

In patients with arterial hypertension concomitant with psoriasis, no statistically significant differences in cytokine levels were observed. On the other hand, in the group of patients diagnosed with diabetes, an increased level of IL-17 was observed. In patients with lipid disorders, the results were similar to the results of patients with diabetes.

Conclusions

It is very important to study immunologic mechanisms responsible for the presence and severity of psoriasis, in order to personalize the therapy in the future and optimize the effect of action on the basic disease and on concomitant disorders.