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Folia Neuropathologica
eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
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Original paper

LncRNA RMST contributes to neuroinflammation after traumatic brain injury by targeting miR-139-5p

Yangwei Zhang
1
,
Yinhua Chen
2
,
Yanli Zhang
3
,
Ye Su
4
,
Juan Wang
4
,
Kang Zhang
5
,
Ningning Zhang
6

  1. Department of Neurology, The Second Clinical College of North Sichuan Medical College, Nanchong Hospital of Beijing Anzhen Hospital & Sichuan Clinical Research Center for Neurological Diseases, Nanchong 637000, China
  2. Department of Neurology, Nanjing BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210019, China
  3. Department of Neuromonitoring, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
  4. Department of Critical Care Medicine, Hebei Yanda Hospital, Hebei 065201, China
  5. Department of Neurosurgery, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu 210000, China
  6. Department of Orthopedics, Affiliated Hospital of Hebei Engineering University, Handan, Hebei Province 056000, China
Folia Neuropathol 2025; 63
DOI: https://doi.org/10.5114/fn.2024.144259
Online publish date: 2025/05/20
Article files
- LncRNA RMST.pdf  [2.55 MB]
- Supplementary material 01648.pdf  [0.19 MB]
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1. Abbasloo E, Khaksari M, Sanjari M, Kobeissy F, Thomas TC. Carvacrol decreases blood-brain barrier permeability post-diffuse traumatic brain injury in rats. Sci Rep 2023; 13: 14546.
2. Altomare M, Bekhor SS, Cioffi SPB, Sacchi M, Renzi F, Spota A, Bini R, Ambrogi F, Pozzi F, Chieregato A, Chiara O, Cimbanassi S. Organ donation after damage control strategy in trauma patients: Experience from first level trauma center in Italy. Life (Basel) 2022; 12.
3. Cao DN, Shi JJ, Wu N, Li J. Modulation of miR-139-5p on chronic morphine-induced, naloxone-precipitated cAMP overshoot in vitro. Metab Brain Dis 2018; 33: 1501-1508.
4. Chen B, Wang W, Lin F, Shi S, Ou S, Yu Y. LINC00470 represses cell autophagy and cisplatin sensitivity of glioma via suppressing PTEN expression. Folia Neuropathol 2023; 61: 88-96.
5. Chen C, Zhang S, Wei Y, Sun X. LncRNA RMST regulates neuronal apoptosis and inflammatory response via sponging miR-150-5p in Parkinson’s disease. Neuroimmunomodulation 2022; 29: 55-62.
6. Cheng H, Sun M, Wang ZL, Wu Q, Yao J, Ren G, Sun XL. LncRNA RMST-mediated miR-107 transcription promotes OGD-induced neuronal apoptosis via interacting with hnRNPK. Neurochem Int 2020; 133: 104644.
7. Devoto C, Lai C, Qu BX, Guedes VA, Leete J, Wilde E, Walker WC, Diaz-Arrastia R, Kenney K, Gill J. Exosomal microRNAs in military personnel with mild traumatic brain injury: Preliminary results from the chronic effects of neurotrauma consortium biomarker discovery project. J Neurotrauma 2020; 37: 2482-2492.
8. Fu J, Zhou Q, Wu B, Huang X, Tang Z, Tan W, Zhu Z, Du M, Wu C, Ma J, Balawi E, Liao ZB. Protective effects and regulatory pathways of melatonin in traumatic brain injury mice model: Transcriptomics and bioinformatics analysis. Front Mol Neurosci 2022; 15: 974060.
9. Guo X, Zhang G, Cai W, Huang F, Qin J, Song X. Long non-coding RNA rhabdomyosarcoma 2-associated transcript contributes to neuropathic pain by recruiting HuR to stabilize DNA methyltransferase 3 alpha mRNA expression in dorsal root ganglion neuron. Front Mol Neurosci 2022; 15: 1027063.
10. He B, Chen W, Zeng J, Tong W, Zheng P. Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury. Aging (Albany NY) 2021; 13: 8127-8145.
11. Hou XX, Cheng H. Long non-coding RNA RMST silencing protects against middle cerebral artery occlusion (MCAO)-induced ischemic stroke. Biochem Biophys Res Commun 2018; 495: 2602-2608.
12. Huang C, Sun L, Xiao C, You W, Sun L, Wang S, Zhang Z, Liu S. Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1. J Neuroinflammation 2023; 20: 39.
13. Jin G, Yang Y, Bi F, Yang M, Ma Y. 5-HT and S100beta values in evaluating severity of cognitive impairment after traumatic brain injury. Folia Neuropathol 2023; 61: 47-52.
14. Jin Y, Jiang L, Wang Y, Huang Y, Yu W, Ma X. lncRNA PRR34-AS1 knockdown represses neuroinflammation and neuronal death in traumatic brain injury by inhibiting microRNA-498 expression. Brain Inj 2023; 37: 611-620.
15. Lei J, Zhang X, Tan R, Li Y, Zhao K, Niu H. Levels of lncRNA GAS5 in plasma of patients with severe traumatic brain injury: Correlation with systemic inflammation and early outcome. J Clin Med 2022; 11: 3319.
16. Li D, Yuan C, Zhao B, Cai G, Xu Y. LncRNA Kcnq1ot1relieves neuropathic pain through downregulation of Myd88. Int Immunopharmacol 2023; 119: 110218.
17. Li J, Wang N, Nie H, Wang S, Jiang T, Ma X, Liu W, Tian K. Long non-coding RNA RMST worsens ischemic stroke via MicroRNA-221-3p/PIK3R1/TGF-beta signaling pathway. Mol Neurobiol 2022; 59: 2808-2821.
18. Li L, Liang J, Fu H. An update on the association between traumatic brain injury and Alzheimer’s disease: Focus on Tau pathology and synaptic dysfunction. Neurosci Biobehav Rev 2021; 120: 372-386.
19. Li XL, Wang B, Yang FB, Chen LG, You J. HOXA11-AS aggravates microglia-induced neuroinflammation after traumatic brain injury. Neural Regen Res 2022; 17: 1096-1105.
20. Liao Y, Gu Y, Wang J, Tian Y, Ni X, Zhou L, Ye Y, Xia G. HSF1 inhibits microglia activation to attenuate neuroinflammation via regulating miR-214-3p and NFATc2 in Parkinson’s disease. Folia Neuropathol 2023; 61: 53-67.
21. Liu C, Peng Z, Li P, Fu H, Feng J, Zhang Y, Liu T, Liu Y, Liu Q, Liu Q, Li D, Wu M. lncRNA RMST suppressed GBM cell mitophagy through enhancing FUS SUMOylation. Mol Ther Nucleic Acids 2020; 19: 1198-1208.
22. Liu N, Sun H, Li X, Cao W, Peng A, Dong S, Yu Z. Downregulation of lncRNA KCNQ1OT1 relieves traumatic brain injury induced neurological deficits via promoting “M2” microglia polarization. Brain Res Bull 2021; 171: 91-102.
23. Long X, Yao X, Jiang Q, Yang Y, He X, Tian W, Zhao K, Zhang H. Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury. J Neuroinflammation 2020; 17: 89.
24. Ma X, Wang Y, Yin H, Hua L, Zhang X, Xiao J, Yuan Q, Wang S, Liu Y, Zhang S, Wang Y. Down-regulated long non-coding RNA RMST ameliorates dopaminergic neuron damage in Parkinson’s disease rats via regulation of TLR/NF-kappaB signaling pathway. Brain Res Bull 2021; 174: 22-30.
25. Mastrorilli V, Farioli Vecchioli S. Physical exercise and traumatic brain injury: is it question of time? Neural Regen Res 2024; 19: 475-476.
26. Meng J, Ding T, Chen Y, Long T, Xu Q, Lian W, Liu W. LncRNA-Meg3 promotes Nlrp3-mediated microglial inflammation by targeting miR-7a-5p. Int Immunopharmacol 2021; 90: 107141.
27. Mira RG, Quintanilla RA, Cerpa W. Mild traumatic brain injury induces mitochondrial calcium overload and triggers the upregulation of NCLX in the hippocampus. Antioxidants (Basel) 2023; 12: 403.
28. Puhakka N, Bot AM, Vuokila N, Debski KJ, Lukasiuk K, Pitkanen A. Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury. PLoS One 2017; 12: e0172521.
29. Qu Y, Wu J, Chen D, Zhao F, Liu J, Yang C, Wei D, Ferriero DM, Mu D. MiR-139-5p inhibits HGTD-P and regulates neuronal apoptosis induced by hypoxia-ischemia in neonatal rats. Neurobiol Dis 2014; 63: 184-193.
30. Tang W, Chai W, Du D, Xia Y, Wu Y, Jiang L, Cheng C, Guo Z, Sun X, Huang Z, Zhong J. The lncRNA-AK046375 upregulates metallothionein-2 by sequestering miR-491-5p to relieve the brain oxidative stress burden after traumatic brain injury. Oxid Med Cell Longev 2022; 2022: 8188404.
31. Tian S, Qu Z, Cao H, Niu X, Qiao Q, Zhang B, Jia L, Wang W. The neuroprotective effect of Dl-3-n-butylphthalide in epileptic rats via inhibiting endoplasmic reticulum stress. Folia Neuropathol 2023; 61: 185-195.
32. Wang L, Liu Y, Yu Z, Gong J, Deng Z, Ren N, Zhong Z, Cai H, Tang Z, Cheng H, Chen S, He Z. Mir-139-5p inhibits glioma cell proliferation and progression by targeting GABRA1. J Transl Med 2021; 19: 213.
33. Wei H, Liu S, Wang T, Li Y, Liu K, Guo Q, Li L. FNDC5 inhibits autophagy of bone marrow mesenchymal stem cells and promo-
34. tes their survival after transplantation by downregulating Sp1. Cell Death Discov 2023; 9: 336.
35. Wu C, Du M, Yu R, Cheng Y, Wu B, Fu J, Tan W, Zhou Q, Balawi E, Liao ZB. A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury. Free Radic Biol Med 2022; 178: 271-294.
36. Xiong A, Li J, Xiong R, Xia Y, Jiang X, Cao F, Lu H, Xu J, Shan F. Inhibition of HIF-1alpha-AQP4 axis ameliorates brain edema and neurological functional deficits in a rat controlled cortical injury (CCI) model. Sci Rep 2022; 12: 2701.
37. Yan J, Gao Y, Huang J, Gao W, Li Y, Lin B. Loss of lncRNA UCA1 ameliorates the injury managed by cerebral ischemia-reperfusion by sponging miR-18a-5p. Folia Neuropathol 2023; 61: 77-87.
38. Yu J, Lu Z, Liu R, Wang P, Ma H, Zhao Y. Characterization of the lncRNA-miRNA-mRNA regulatory network to reveal potential functional competing endogenous RNAs in traumatic brain injury. Front Neurosci 2022; 16: 1089857.
39. Zhao C, Yang F, Wei X, Zhang J. miR-139-5p upregulation alleviated spontaneous recurrent epileptiform discharge-induced oxidative stress and apoptosis in rat hippocampal neurons via regulating the Notch pathway. Cell Biol Int 2021; 45: 463-476.
40. Zhao L, Zhang M, Yan F, Cong Y. Knockdown of RMST impedes neuronal apoptosis and oxidative stress in OGD/R-induced ischemic stroke via depending on the miR-377/SEMA3A signal network. Neurochem Res 2021; 46: 584-594.
Copyright: © 2025 Mossakowski Medical Research Centre Polish Academy of Sciences and the Polish Association of Neuropathologists. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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