MK-2206 dihydrochloride ameliorates the neuronal function 
in spinal cord injured rats by reducing oxidative stress 
and modulating the PI3K/Akt pathway

Jinjuan Wang; Juanrong Zhou; Alok Tripathi

doi:10.5114/fn.2025.158298

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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abstract:

Original paper

MK-2206 dihydrochloride ameliorates the neuronal function in spinal cord injured rats by reducing oxidative stress and modulating the PI3K/Akt pathway

Jinjuan Wang

¹

,

Juanrong Zhou

²

,

Alok Shiomurti Tripathi

³

Department of Neurosurgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710005, China
Department of Pharmacy, Xi’an GaoXin Hospital, Xi’an, 710075, China
Department of Pharmacology, Era College of Pharmacy, Era University, Lucknow (UP), India

Folia Neuropathol 2026; 64 (1)

DOI: https://doi.org/10.5114/fn.2025.158298

Online publish date: 2026/02/09

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Introduction
Spinal cord injury (SCI) is one of the major causes of paralysis and physical inability, and its management remains a challenge. The present study evaluated the effect of MK-2206 dihydrochloride in rats with SCI.

Material and methods
An impactor device was used to induce SCI, which was treated with MK-2206 12 mg/kg, s.c., daily for 10 days. The effect of MK-2206 on SCI was determined by estimating the locomotor function, inflammatory mediators, and oxidative stress parameters in all groups of rats. Western blot assay was performed to estimate the expression of phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt) protein in the spinal tissue of SCI rats. Moreover, the effect of MK-2206 on the apoptosis of spinal tissue of SCI rats was assessed.

Results
Study data suggest that treatment with MK-2206 reverses the alteration in the neuronal function in SCI rats. Cytokines and oxidative stress were observed to be ameliorated in the MK-2206-treated group compared to the SCI group. Moreover, treatment with MK-2206 attenuated PI3K and Akt protein expression in the spinal tissue of SCI rats. Treatment with MK-2206 significantly reduced the apoptosis of spinal tissue in SCI rats.

Conclusions
The data suggest that treatment with MK-2206 prevents injury to the neuronal tissue in SCI rats by modulating the PI3k/Akt pathway.

keywords:

MK-2206 dihydrochloride ameliorates the neuronal function in spinal cord injured rats by reducing oxidative stress and modulating the PI3K/Akt pathway

Jinjuan Wang 1 , Juanrong Zhou 2 , Alok Shiomurti Tripathi 3

spinal cord injury, oxidative stress, MK-2206, reactive oxygen species, cytokines, neurodegeneration

Jinjuan Wang

¹

,

Juanrong Zhou

²

,

Alok Shiomurti Tripathi

³