Mechanisms induced by allergen immunotherapy:  state 
of knowledge in 2018

Marek Jutel; Paweł Gajdanowicz

doi:10.5114/pja.2018.80735

eISSN: 2391-6052
ISSN: 2353-3854

Alergologia Polska - Polish Journal of Allergology

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abstract:

Guidelines/recommendations

Mechanisms induced by allergen immunotherapy: state of knowledge in 2018

Marek Jutel

,

Paweł Gajdanowicz

Alergologia Polska – Polish Journal of Allergology 2018; 5, 4: 175–179

DOI: https://doi.org/10.5114/pja.2018.80735

Online publish date: 2018/12/27

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Allergen immunotherapy (AIT) with specific allergen is currently regarded as the only causal treatment of allergic diseases. Efficacy of AIT has been confirmed for both inhalant allergy as well as for mild to moderate atopic asthma. Allergen immunotherapy modifies multiple functions of Th2, Treg, Breg, ILC (and the others) cells engaged into pathogenesis of allergic inflammation. The most frequent forms and ways of application of AIT are subcutaneous AIT and sublingual AIT. According to the current guidelines 3-years lasting treatment with AIT is regarded as sufficient to achieve expected therapeutic outcomes.

keywords:

Mechanisms induced by allergen immunotherapy: state of knowledge in 2018

Marek Jutel , Paweł Gajdanowicz

immunotherapy, allergen, immunological mechanisms

Marek Jutel

,

Paweł Gajdanowicz