Advances in Dermatology and Allergology
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ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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6/2025
vol. 42
 
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Original paper

Microneedling combined with different topically applied medications in treatment of vitiligo patients

Nader N. Nazmy
1
,
Neveen Emad Sorour
1
,
Esraa Alaa Isa Abdullah
1
,
Samah Ezzat Ibrahim
1

  1. Dermatology, Venereology and Andrology Department, Faculty of Medicine, Benha University, Benha, Egypt
Adv Dermatol Allergol 2025; XLII (6): 606–614
Online publish date: 2026/01/12
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3. Bae JM, Kwon SH, Ju HJ, et al. Suberythemic and erythemic doses of a 308-nm excimer laser treatment of stable vitiligo in combination with topical tacrolimus: a randomized controlled trial. J Am Acad Dermatol 2020; 83: 1463-4.
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10. Wanitphakdeedecha R, Ungaksornpairote C, Kaewkes A, et al. The efficacy of two formulations of botulinum toxin type A for masseter reduction: a split-face comparison study. J Dermatolog Treat 2017; 28: 443-6.
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15. Gauthier Y, Lepreux S, Cario-Andre M, et al. Varicella-zoster virus in actively spreading segmental vitiligo skin: pathological, immunochemical, and ultrastructural findings (a first and preliminary study). Pigment Cell Melanoma Res 2023; 36: 78-85.
16. Nofal A, Eldeeb F, Shalaby M, et al. Microneedling combined with pimecrolimus, 5-fluorouracil, and trichloroacetic acid in the treatment of vitiligo: a comparative study. Dermatol Ther 2022; 35: e15294.
17. Attwa EM, Khashaba SA, Ezzat NA. Evaluation of the additional effect of topical 5-fluorouracil to needling in the treatment of localized vitiligo. J Cosmet Dermatol 2020; 19: 1473-8.
18. Kohli I, Isedeh P, Al-Jamal M, et al. Three-dimensional imaging of vitiligo. Exp Dermatol 2015; 24: 879-80.
19. Njoo MD, Das PK, Bos JD, et al. Association of the Köbner phenomenon with disease activity and therapeutic responsiveness in vitiligo vulgaris. Arch Dermatol 1999; 135: 407-13.
20. Zahra FT, Adil M, Amin SS, et al. Efficacy of topical 5% 5-fluorouracil with needling versus 5% 5-fluorouracil alone in stable vitiligo: a randomized controlled study. J Cutan Aesthet Surg 2020; 13: 197-203.
21. El-Mofty M, Mostafa WZ, Esmat S, et al. Site-oriented depigmentation in vitiligo patients using Q-switched Nd: YAG laser (1,064/532 nm), cryotherapy and chemical peels: a comparative study. Dermatol Ther 2019; 32: e13052.
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24. Abdou AG, Farag AGA, Rashwan M, et al. The clinical and pathological effectiveness of microneedling and topical 5-fluorouracil in vitiligo treatment: an association with matrix metalloproteinase 2 immunohistochemical expression. J Cosmet Dermatol 2022; 21: 2153-61.
25. Ibrahim SS. The efficacy of tricholoroacetic acid 70% after microneedling in the treatment of non-segmental vitiligo. Zagazig Univ Med J 2022; 28: 966-73.
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29. Schallreuter KU, Elwary SM, Gibbons NC, et al. Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo. Biochem Biophys Res Commun 2004; 315: 502-8.
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