eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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5/2018
vol. 35
 
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abstract:
Original paper

Morphea and antithyroid antibodies

Aleksandra Dańczak-Pazdrowska, Adriana Polańska, Joanna Synakiewicz, Edyta Gurgul, Marta Molińska-Glura, Marek Ruchała, Ryszard Żaba, Zygmunt Adamski

Adv Dermatol Allergol 2018; XXXV (5): 470-473
Online publish date: 2018/07/19
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Introduction
Morphea, also known as localized scleroderma, is an autoimmune skin disease which is characterized by excessive accumulation of collagen that leads to the thickening of the dermis and subcutaneous tissue. There is an unclear relationship between morphea and other autoimmune diseases, especially related to the thyroid gland.

Aim
To determine the occurrence of increased antithyroid antibodies in patients with morphea in relation to the clinical manifestations of the disease.

Material and methods
Forty-two Caucasian patients with different forms of morphea were included into the study. To determine the thyroid status, thyrotropin (TSH), anti-peroxidase antibodies (TPO-Ab), anti-thyroglobulin antibodies (Tg-Ab) were evaluated with the use of the electrochemiluminescence method and TSH receptor autoantibodies (TRAb) – with the use of the radioimmunoassay method.

Results
Increased levels of antithyroid antibodies were observed in 6 cases in relation to TPO-Ab (14.3%), in 4 cases in relation to of Tg-Ab (9.5%) and in 1 patient in relation to TRAb (2.3%). There was no difference in the level of antithyroid antibodies between circumscribed and generalized forms of morphea.

Conclusions
Although morphea is an autoimmune disease, it does not seem to be associated with increased prevalence of positive antithyroid antibodies. We conclude that there is no need to perform routine laboratory tests for thyroid disorders in patients with morphea.

keywords:

morphea, anti-peroxidase antibodies, localized scleroderma, antithyroid antibodies

references:
Fett N, Werth VP. Update on morphea: part I. Epidemiology, clinical presentation, and pathogenesis. J Am Acad Dermatol 2011; 64: 217-28.
Careta MF, Romiti R. Localized scleroderma: clinical spectrum and therapeutic update. An Bras Dermatol 2015; 90: 62-73.
Distler O, Cozzio A. Systemic sclerosis and localized scleroderma: current concepts and novel targets for therapy. Semin Immunopathol 2016; 38: 87-95.
Gill L, Zarbo A, Isedeh P, et al. Comorbid autoimmune diseases in patients with vitiligo: a cross-sectional study. J Am Acad Dermatol 2016; 74: 295-302.
Szyper-Kravitz M, Marai I, Shoenfeld Y. Coexistence of thyroid autoimmunity with other autoimmune diseases: friend or foe? Additional aspects on the mosaic of autoimmunity. Autoimmunity 2005; 38: 247-55.
Finkelstein E, Amichai B, Metzker A. Coexistence of vitiligo and morphea: a case report and review of the literature. J Dermatol 1995; 22: 351-3.
Brenner W, Diem E, Gschnait F. Coincidence of vitiligo, alopecia areata, onychodystrophy, localized scleroderma and lichen planus. Dermatologica 1979; 159: 356-60.
Leitenberger JJ, Cayce RL, Haley RW, et al. Distinct autoimmune syndromes in morphea: a review of 245 adult and pediatric cases. Arch Dermatol 2009; 145: 545-50.
González-López MA, Drake M, Gonzalez-Vela MC, et al. Generalized morphea and primary biliary cirrhosis coexisting in a male patient. J Dermatol 2006; 33: 709-13.
Khalifa M, Ben Jazia E, Hachfi W, et al. Autoimmune hepatitis and morphea: a rare association. Gastroenterol Clin Biol 2006; 30: 917-8.
Dervis E, Acbay O, Barut G, et al. Association of vitiligo, morphea, and Hashimoto’s thyroiditis. Int J Dermatol 2004; 43: 236-7.
Kim HS, Chun YS, Hann SK, Park WH. A case of linear scleroderma and myasthenia gravis. J Dermatol 2000; 27: 31-4.
Gill L, Zarbo A, Isedeh P, et al. Comorbid autoimmune diseases in patients with vitiligo: a cross-sectional study. J Am Acad Dermatol 2016; 74: 295-302.
Bonifati C, Impara G, Morrone A, et al. Simultaneous occurrence of linear scleroderma and homolateral segmental vitiligo. J Eur Acad Dermatol Venereol 2006; 20: 63-5.
Majeed M, Al-Mayouf S, MAl-Sabban E, Bahabri S. Coexistent linear scleroderma and juvenile systemic lupus erythematosus. Pediatr Dermatol 2000; 17: 456-9.
Kreuter A, Krieg T, Worm M, et al. German guidelines for the diagnosis and therapy of localized scleroderma. J Dtsch Dermatol Ges 2016; 14: 199-216.
Elhai M, Avouac J, Kahan A, Allanore Y. Systemic sclerosis at the crossroad of polyautoimmunity. Autoimmun Rev 2013; 12: 1052-7.
Laxer RM, Zulian F. Localized scleroderma. Curr Opin Rheumatol 2006; 18: 606-13.
Okayasu I, Hara Y, Nakamura K, Rose NR. Racial and age-related differences in incidence and severity of focal autoimmune thyroiditis. Am J Clin Pathol 1994; 101: 698-702.
Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002; 87: 489-99.
Arif T, Hassan I. Generalized morphea and hypothyroidism: case report of a rare association. J Pakistan Assoc Dermatol 2015; 25: 223-6.
Lee HJ, Kim MY, Ha SJ, Kim JW. Two cases of morphea associated with Hashimoto’s thyroiditis. Acta Derm Venereol 2002; 82: 58-9.
Okayasu I, Hatakeyama S, Tanaka Y, et al. Is focal chronic autoimmune thyroiditis an age-related disease? Differences in incidence and severity between Japanese and British. J Pathol 1991; 163: 257-64.
Pedersen IB, Knudsen N, Jørgensen T, et al. Thyroid peroxidase and thyroglobulin autoantibodies in a large survey of populations with mild and moderate iodine deficiency. Clin Endocrinol (Oxf) 2003; 58: 36-42.
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