Polish Journal of Pathology
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ISSN: 1233-9687
Polish Journal of Pathology
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Original paper

Neural proximity, vascular remodeling, and perineural immune exclusion across the cervical neoplasia spectrum – a whole-slide, nerve-anchored spatial analysis of 135 cases

Giorgi-Jemal Gogitidze
1, 2
,
Shota Kepuladze
3
,
George Burkadze
1

  1. Department of Pathology, Tbilisi State Medical University, Tbilisi, Georgia
  2. Department of Pathologic Anatomy and Molecular Pathology, Scientific-Diagnostic Laboratory, Tbilisi State Medical University, Tbilisi, Georgia
  3. Department of Pathologic Anatomy and Molecular Pathology, Tbilisi State Medical University, Tbilisi, Georgia
Pol J Pathol 2025; 76 (4)
Online publish date: 2026/01/28
Article file
- Neural proximity.pdf  [3.30 MB]
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1. Hughes RT, Läck CM, Sachs JR, Hiatt KD, Smith S, Ste- ber CR, et al. Predicting extranodal extension with preoperative contrast-enhanced ct in patients with oropharyngeal squamous cell carcinoma. Radiol Imaging Cancer 2025; 7: e240127.
2. Balan TA, Bălan R, Socolov D, Gheorghita V, Buţureanu T, Păvăleanu I, et al. Pregnancy-related precancerous cervical lesions: pathogenesis, diagnosis, evolution, and impact upon gestation and fertility. journal of clinical medicine. J Clin Med 2024; 13: 6718.
3. Vigdorovits A, Olteanu G, Ţică O, Pașcalău A, Boros M, Pop O. Predicting the evolution of lung squamous cell carcinoma in situ using computational pathology. Bioengineering (Basel) 2025; 12: 377.
4. Zhang Z, Liu M, An Y, Gao C, Wang T, Zhang Z, et al. Targeting immune microenvironment in cervical cancer: current research and advances. J Translat Med 2025; 23: 888.
5. Huang S, Zhu J, Yu L, Huang Y, Hu Y. Cancer-nervous system crosstalk: from biological mechanism to therapeutic opportunities. Mol Cancer 2025; 24: 133.
6. Zhang X, Liu L, Chai Y, Zhang J, Deng Q, Chen X. Reimagi- ning the meninges from a neuroimmune perspective: a boundary, but not peripheral. J Neuroinflammation; 2024; 21: 299.
7. Dudley AC, Griffioen AW. Pathological angiogenesis: mechanisms and therapeutic strategies. Angiogenesis 2023; 26: 313.
8. Shalabi S, Belayachi A, Larrivée B. Involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironment. Front Immunol 2024; 15: 1284629.
9. Wang H, Huo R, He K, Li C, Zhang S, Yu M, et al. Perineural invasion in colorectal cancer: mechanisms of action and clinical relevance. Cell Oncol 2023; 47: 1.
10. Loopik D, Bentley HA, Eijgenraam MN, IntHout J, Bek- kers RLM, Bentley J. The natural history of cervical intraepithelialneoplasia grades 1, 2, and 3: a systematic review and meta-analysis. J Lower Genital Tract Dis 2021; 25: 221.
11. Gao X, Wang Q, Huang T, Xu C, Yang X, Zhang L, et al. Cervical cancer-produced neuromedin-B reprograms Schwann cells to initiate perineural invasion. Cell Death Dis 2024; 15: 636.
12. Pu T, Sun J, Ren G, Li H. Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications. Signal Transduct Target Ther 2025; 10: 176.
13. Yang Y, Cui J, Kong Y, Hou Y, Ma C. Organoids: new frontiers in tumor immune microenvironment research. Front Immunol 2024; 15: 1422031.
14. Ahmed I, Zhang W, Cheung P, Basnet V, Ali Z, Tse M, et al. AI-based virtual immunocytochemistry for rapid and robust fine needle aspiration biopsy diagnosis. Diagn Pathol 2025; 20: 86.
15. Weber S, Menees KB, Park J, Agin-Liebes J, Lin CC, Alca-lay RN, et al. Distinctive CD56dim NK subset profiles and increased NKG2D expression in blood NK cells of Parkinson’s disease patients. NPJ Parkinsons Dis 2024; 10: 36.
16. Kusch N, Storm JJ, Macioszek A, Kisselmann E, Knabbe C, Kaltschmidt B, et al. A Critical role of culture medium selection in maximizing the purity and expansion of natural killer cells. Cells 2024; 13: 1148.
17. Kuehl M, Okabayashi Y, Wong MN, Gernhold L, Gut G, Kaiser N, et al. Pathology-oriented multiplexing enables integrative disease mapping. Nature 2025; 644: 516-526.
Copyright: © 2026 Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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