Normal immunoglobulin (IgG, IgA, and IgM) values in healthy children without newborn period

Introduction:
Immunoglobulins (Ig) are an important element of the adaptive immune system; they are produced against antigens in plasma cells and have a specific association with antigens. Determination of normal immunoglobulin values will guide the diagnosis, treatment, and follow-up of immunodeficiency diseases. Our studies determine the IgG, IgA, and IgM levels in healthy children and the reference values specific to our region.

Material and methods:
Inclusion criteria for the study were 200 healthy children aged 1 month to 18 years, with no known history of chronic disease, no suspected infection, no drug use, no congenital disease or anomaly, and consent for the study. Venous blood samples from the patients were studied in the Medical Microbiology Laboratory by nephelometry method according to the instructions.

Results:
The 200 children included in our study were divided into ten groups according to their age groups. Serum IgG values increased gradually until the age of 6–8, then reached a plateau and approached the adult level. The serum IgA level started at very low values in the first months, gradually increasing after the age of 2 and reaching the adult level at 18. Serum IgM level approaches the adult level 4–5 years after it was contacted at similar values.

Conclusions:
Our study provided data for normal serum IgG, IgA, and IgM values in healthy non-neonatal children. Immunoglobulin values in healthy children have been studied in a small number of different places and clinics, and it is aimed to obtain data from our region. Our study is considered one of our country’s original and reliable reference sources.