ORIGINAL PAPER
Dynamics of changes of the BNP concentration in patients with stable angina pectoris qualified for PTCA. Dependence on the selected morphological and haemodynamic parameters

Introduction: Cardiomyocytes of human heart ventricles synthesize and generate BNP. The effect of BNP on the volume of the vascular bed contributes significantly to successful arterial pressure control. The usefulness of its determination has been proved in acute coronary syndromes, and chronic heart failure. The aim of the study was to estimate the BNP concentration in patients with stable angina pectoris during temporary myocardial ischaemia in the course of PTCA and the assessment of the effect of selected morphological and haemodynamic parameters on the BNP concentration. Material and methods: The study comprised 27 patients, mean age 57.4 years with a clinically confirmed diagnosis of ischemic disease. All of them were qualified for coronary angiography to evaluate the condition of coronary vessels and to undertake emergency treatment if necessary. During PTCA blood was collected three times from the coronary sinus of the qualified patients: before the procedure, at rest and after the first and second inflations of a balloon in the coronary artery. Echocardiography was performed prior to PTCA in all the patients. LVMI, EF and LA-d were estimated. Results: A nearly double increase of the BNP concentration was observed after the first and second balloon inflations. A correlation was discovered between the determined concentrations of BNP and LVMI and EF. No correlation was found between BNP concentration and LA-d. Conclusions: The obtained results confirm significant importance of BNP concentration determination in clinical practice in order to evaluate left ventricular function. The ventricular muscle seems to play a key role in the BNP