eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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5/2018
vol. 35
 
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abstract:
Original paper

Omalizumab improves forced expiratory volume in 1 second in patients with severe asthma

Krzysztof Pałgan, Magdalena Żbikowska-Götz, Kinga Lis, Elżbieta Chrzaniecka, Zbigniew Bartuzi

Adv Dermatol Allergol 2018; XXXV (5): 495-497
Online publish date: 2018/07/19
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Introduction
Asthma is a multiphenotypic disease, and therapeutic managenment in patients with severe asthma is particulary difficult, with conventional treatment of severe asthma showing poor efficacy.

Aim
To analyse forced expiratory volume in 1 s (FEV1) following the adminstration of omalizumab.

Material and methods
Six patinents (mean age: 50 ±12.6) with severe, uncontrolled asthma according to the GINA guidelines were enrolled in the study.

Results
Treatment with omalizumab increased in all subjects FEV1 by 17.28 ±13.4% after months and 18.57 ±13.4% after 12 months of treatment.

Conclusions
These results provides further evidence that therapy with omalizumab improves spiromtric parameters in severe asthma.

keywords:

asthma, omalizumab, spirometry, forced expiratory volume in 1 s

references:
Global Initiative for Asthma (GINA), National Heart, Lung and Blood Institute (NHLBI) Global strategy for asthma management and prevention. Bethesda (MD): Global Initiative for Asthma (GINA), National Heart, Lung and Blood Institute (NHLBI); 2006. Available from: www.ginasthma.com.
Raoufy MR, Ghafari T, Darooei R, et al. Classification of asthma based on nonlinear analysis of breathing pattern. PLoS One 2016; 11: e0147976.
Busse W, Corren J, Lanier BQ, et al. Omalizumab, antiIgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J Allergy Clin Immunol 2001; 108: 184-90.
Kupryś-Lipińska I, Majak P, Molinska J, Kuna P. Effectiveness of the Polish program for the treatment of severe allergic asthma with omalizumab: a single-center experience. BMC Pulm Med 2016; 16: 61.
Lai T, Wang S, Xu Z, et al. Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis. Sci Rep 2015; 5: 8191.
Hatipoğlu U, Subramanian A, Campbell T, et al. Intrasubject variability in total IgE levels in patients with moderate to severe persistent allergic asthma over 1 year. J Allergy Clin Immunol Pract 2016; 4: 691-6.e1.
Siroux V, Boudier A, Bousquet J, et al. Asthma control assessed in the EGEA epidemiological survey and health-related quality of life. Respir Med 2012; 106: 820-8.
Cazzoletti L, Marcon A, Janson C, et al. Asthma control in Europe: a real-world evaluation based on an international population-based study. J Allergy Clin Immunol 2007; 120: 1360-7.
Kämpe M, Lisspers K, Ställberg B, et al. Determinants of uncontrolled asthma in a Swedish asthma population: cross-sectional observational study. Eur Clin Respir J 2014; 1: 10.3402/ecrj.v1.24109.
Bartuzi Z, Bodzenta-Łukaszyk A, Kuna P, et al. The statement of the Polish Society of Allergology regarding necessary changes in therapeutic program of severe IgE-mediated allergic asthma with omalizumab. Pneumonol Alergol Pol 2015; 83: 335-8.
MacGlashan DW Jr, Bochner BS, Adelman DC, et al. Down-regulation of FcRI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J Immunol 1997; 158: 1438-45.
Galli SJ, Tsai M. IgE and mast cells in allergic disease. Nat Med 2012; 18: 693-704.
Djukanović R, Wilson SJ, Kraft M, et al. Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am J Respir Crit Care Med 2004; 170: 583-93.
Riccio AM, Dal Negro RW, Micheletto C, et al. Omalizumab modulates bronchial reticular basement membrane thickness and eosinophil infiltration in severe persistent allergic asthma patients. Int J Immunopathol Pharmacol 2012; 25: 475-84.
Clavenna MJ, Turner JH, Samuelson M, et al. Differential effect of omalizumab on pulmonary function in patients with allergic asthma with and without chronic rhinosinusitis. Allergy Asthma Proc 2016; 37: 23-6.
Pałgan K, Bartuzi Z. Angiogenesis in bronchial asthma. Int J Immunopathol Pharmacol 2015; 28: 415-20.
Pałgan K, Dziedziczko A, Bartuzi Z. Alternations of bronchial smooth muscle and effect of therapy on remodeling in asthma. Pol Merkur Lekarski 2006; 21: 5-7.
Mauri P, Riccio AM, Rossi R, et al. Proteomics of bronchial biopsies: galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients. Immunol Lett 2014; 162: 2-10.
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