Original article<br>Immunoexpression of gemins 2 and 4 in the rat spinal cord. Is the SMN complex a new target in investigations of sporadic amyotrophic lateral sclerosis pathogenesis?

Janina Rafałowska; Dorota Sulejczak; Roman Gadamski; Dorota Dziewulska

doi:10.5114/fn.2012.32373

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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4/2012
vol. 50

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Original article
Immunoexpression of gemins 2 and 4 in the rat spinal cord. Is the SMN complex a new target in investigations of sporadic amyotrophic lateral sclerosis pathogenesis?

Janina Rafałowska

,

Dorota Sulejczak

,

Roman Gadamski

,

Dorota Dziewulska

Folia Neuropathol 2012; 50 (4): 390-396

DOI: https://doi.org/10.5114/fn.2012.32373

Online publish date: 2012/12/24

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AMA

Rafałowska J, Sulejczak D, Gadamski R, Dziewulska D. Original articleImmunoexpression of gemins 2 and 4 in the rat spinal cord. Is the SMN complex a new target in investigations of sporadic amyotrophic lateral sclerosis pathogenesis?. Folia Neuropathologica. 2012;50(4):390-396. doi:10.5114/fn.2012.32373.

APA

Rafałowska, J., Sulejczak, D., Gadamski, R.,  & Dziewulska, D. (2012). Original articleImmunoexpression of gemins 2 and 4 in the rat spinal cord. Is the SMN complex a new target in investigations of sporadic amyotrophic lateral sclerosis pathogenesis?. Folia Neuropathologica, 50(4), 390-396. https://doi.org/10.5114/fn.2012.32373

Chicago

Rafałowska, Janina, Dorota Sulejczak, Roman Gadamski,  and Dorota Dziewulska. 2012. "Original articleImmunoexpression of gemins 2 and 4 in the rat spinal cord. Is the SMN complex a new target in investigations of sporadic amyotrophic lateral sclerosis pathogenesis?". Folia Neuropathologica 50 (4): 390-396. doi:10.5114/fn.2012.32373.

Harvard

Rafałowska, J., Sulejczak, D., Gadamski, R.,  and Dziewulska, D. (2012). Original articleImmunoexpression of gemins 2 and 4 in the rat spinal cord. Is the SMN complex a new target in investigations of sporadic amyotrophic lateral sclerosis pathogenesis?. Folia Neuropathologica, 50(4), pp.390-396. https://doi.org/10.5114/fn.2012.32373

MLA

Rafałowska, Janina et al. "Original articleImmunoexpression of gemins 2 and 4 in the rat spinal cord. Is the SMN complex a new target in investigations of sporadic amyotrophic lateral sclerosis pathogenesis?." Folia Neuropathologica, vol. 50, no. 4, 2012, pp. 390-396. doi:10.5114/fn.2012.32373.

Vancouver

Rafałowska J, Sulejczak D, Gadamski R, Dziewulska D. Original articleImmunoexpression of gemins 2 and 4 in the rat spinal cord. Is the SMN complex a new target in investigations of sporadic amyotrophic lateral sclerosis pathogenesis?. Folia Neuropathologica. 2012;50(4):390-396. doi:10.5114/fn.2012.32373.

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Sporadic amyotrophic lateral sclerosis (sALS) is a neurodegenerative disease leading to degeneration and loss of motoneurons in different structures of the nervous system. Although aetiology of the disease is unknown, it is hypothesized that the survival motor neuron (SMN) protein which protects motoneurons in spinal muscular atrophy, may play a similar role in ALS. Relatively little is known about normal expression and functions of the SMN complex compounds, i.e. SMN protein and the related gemins. Therefore, we have decided to examine the physiological expression of SMN and gemins 2 and 4 in spinal cords of healthy Wistar rats at different age using immunofluorescence and immunohistochemical methods. Our study revealed that (1) in rat spinal cord neurons, the immunoexpression of SMN and gemins 2 and 4 is present through the whole animal lifespan although the reactive cells reveal different intensity of the immunolabeling, (2) both SMN and gemin 2, and SMN and gemin 4 are present in the same motoneurons, (3) immunoexpression of gemin 2 and 4 decreases slightly with aging.

keywords:

Original articleImmunoexpression of gemins 2 and 4 in the rat spinal cord. Is the SMN complex a new target in investigations of sporadic amyotrophic lateral sclerosis pathogenesis?

Janina Rafałowska , Dorota Sulejczak , Roman Gadamski , Dorota Dziewulska

SMN, gemin, ALS, rat

Original article
Immunoexpression of gemins 2 and 4 in the rat spinal cord. Is the SMN complex a new target in investigations of sporadic amyotrophic lateral sclerosis pathogenesis?

Janina Rafałowska

,

Dorota Sulejczak

,

Roman Gadamski

,

Dorota Dziewulska