Abstract
1/2011
vol. 49
Original article
Are cardiomyocytes able to generate pre-amyloid peptides?
Folia Neuropathol 2011; 49 (1): 64-70
Online publish date: 2011/03/31
We performed ultrastructural testing of a cardiac biopsy taken from a heart with amyloidosis in which transthyretin mutation and light chain A amyloidosis were excluded. Cardiomyocytes of the affected heart showed accumulation of endosomal-like structures in which soluble amyloid oligomeric conformation was deposited. Intracellular accumulation of β -amyloid as well as phosphorylated tau protein seen in the immunohistochemical study suggest that the heart tissue may generate an amyloidogenic peptide leading to cardiomyocyte destruction and heart dysfunction.
Keywords
cardiomyocytes, amyloidosis, β -amyloid, phosphorylated tau protein
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