eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
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1/2011
vol. 49
 
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abstract:

Original article
Are cardiomyocytes able to generate pre-amyloid peptides?

Anna Fidziańska
,
Ewa Walczak
,
Paweł Bekta
,
Lidia Chojnowska

Folia Neuropathol 2011; 49 (1): 64-70
Online publish date: 2011/03/31
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We performed ultrastructural testing of a cardiac biopsy taken from a heart with amyloidosis in which transthyretin mutation and light chain A amyloidosis were excluded. Cardiomyocytes of the affected heart showed accumulation of endosomal-like structures in which soluble amyloid oligomeric conformation was deposited. Intracellular accumulation of β -amyloid as well as phosphorylated tau protein seen in the immunohistochemical study suggest that the heart tissue may generate an amyloidogenic peptide leading to cardiomyocyte destruction and heart dysfunction.
keywords:

cardiomyocytes, amyloidosis, β -amyloid, phosphorylated tau protein


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