Original paper<br>Association of the rs1801133 variant in the <i>MTHFR </i>gene and sporadic Parkinson’s disease

Silvia García; Ramón Mauricio Coral-Vázquez; Martha P. Gallegos-Arreola; Luis Ángel Montes-Almanza; Patricia Canto; Froylan Arturo García-Martínez; Gerardo Chavira-Hernández; Carlos Palma-Flores; Luis Dávila-Maldonado; Carlos F. Cuevas-García; Luz Berenice López Hernández

doi:10.5114/fn.2015.49971

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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Original paper
Association of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease

Silvia García

,

Ramón Mauricio Coral-Vázquez

,

Martha P. Gallegos-Arreola

,

Luis Ángel Montes-Almanza

,

Patricia Canto

,

Froylan Arturo García-Martínez

,

Gerardo Chavira-Hernández

,

Carlos Palma-Flores

,

Luis Dávila-Maldonado

,

Carlos F. Cuevas-García

,

Luz Berenice López Hernández

Folia Neuropathol 2015; 53 (1): 24-28

DOI: https://doi.org/10.5114/fn.2015.49971

Online publish date: 2015/03/24

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AMA

García S, Coral-Vázquez R, Gallegos-Arreola M, et al. Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease. Folia Neuropathologica. 2015;53(1):24-28. doi:10.5114/fn.2015.49971.

APA

García, S., Coral-Vázquez, R., Gallegos-Arreola, M., Montes-Almanza, L., Canto, P.,  & García-Martínez, F. et al. (2015). Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease. Folia Neuropathologica, 53(1), 24-28. https://doi.org/10.5114/fn.2015.49971

Chicago

García, Silvia, Ramón Mauricio Coral-Vázquez, Martha P. Gallegos-Arreola, Luis Ángel Montes-Almanza, Patricia Canto, Froylan Arturo García-Martínez,  and Gerardo Chavira-Hernández et al. 2015. "Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease". Folia Neuropathologica 53 (1): 24-28. doi:10.5114/fn.2015.49971.

Harvard

García, S., Coral-Vázquez, R., Gallegos-Arreola, M., Montes-Almanza, L., Canto, P., García-Martínez, F., Chavira-Hernández, G., Palma-Flores, C., Dávila-Maldonado, L., Cuevas-García, C.,  and Hernández, L. (2015). Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease. Folia Neuropathologica, 53(1), pp.24-28. https://doi.org/10.5114/fn.2015.49971

MLA

García, Silvia et al. "Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease." Folia Neuropathologica, vol. 53, no. 1, 2015, pp. 24-28. doi:10.5114/fn.2015.49971.

Vancouver

García S, Coral-Vázquez R, Gallegos-Arreola M, Montes-Almanza L, Canto P, García-Martínez F et al. Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease. Folia Neuropathologica. 2015;53(1):24-28. doi:10.5114/fn.2015.49971.

The MTHFR gene has been reported as a susceptibility locus for sporadic Parkinson’s disease (sPD). The functional variant rs1801133 has been linked to hyperhomocysteinemia and dopaminergic cell death. Among different populations, Mexican-Mestizos (most present-day Mexicans) have the highest frequency of this variant. Therefore, we sought to determine a possible association of rs1801133 with SPD. In total, 356 individuals were included: 140 patients with PD, diagnosed according to the Queen Square Brain Bank criteria, and 216 neurologically healthy controls. Genotyping was performed using TaqMan probes for rs1801133 and real-time PCR. Logistic regression analysis with adjustment for smoking and gender was used to test for an association between genotype and SPD. The CC genotype was associated with SPD; exp() = 2.06; 95% CI: 1.101-3.873, p = 0.024. No association with age at onset, cognitive impairment or gender was found in our study group. Our data suggest an important role of MTHFR gene variants in SPD.

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Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease

Silvia García , Ramón Mauricio Coral-Vázquez , Martha P. Gallegos-Arreola , Luis Ángel Montes-Almanza , Patricia Canto , Froylan Arturo García-Martínez , Gerardo Chavira-Hernández , Carlos Palma-Flores , Luis Dávila-Maldonado , Carlos F. Cuevas-García , Luz Berenice López Hernández

rs1801133, MTHFR, Parkinson’s disease, common variants, C677T, Mexico

Original paper
Association of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease