eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
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1/2015
vol. 53
 
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abstract:

Original paper
Association of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease

Silvia García
,
Ramón Mauricio Coral-Vázquez
,
Martha P. Gallegos-Arreola
,
Luis Ángel Montes-Almanza
,
Patricia Canto
,
Froylan Arturo García-Martínez
,
Gerardo Chavira-Hernández
,
Carlos Palma-Flores
,
Luis Dávila-Maldonado
,
Carlos F. Cuevas-García
,
Luz Berenice López Hernández

Folia Neuropathol 2015; 53 (1): 24-28
Online publish date: 2015/03/24
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The MTHFR gene has been reported as a susceptibility locus for sporadic Parkinson’s disease (sPD). The functional variant rs1801133 has been linked to hyperhomocysteinemia and dopaminergic cell death. Among different populations, Mexican-Mestizos (most present-day Mexicans) have the highest frequency of this variant. Therefore, we sought to determine a possible association of rs1801133 with SPD. In total, 356 individuals were included: 140 patients with PD, diagnosed according to the Queen Square Brain Bank criteria, and 216 neurologically healthy controls. Genotyping was performed using TaqMan probes for rs1801133 and real-time PCR. Logistic regression analysis with adjustment for smoking and gender was used to test for an association between genotype and SPD. The CC genotype was associated with SPD; exp() = 2.06; 95% CI: 1.101-3.873, p = 0.024. No association with age at onset, cognitive impairment or gender was found in our study group. Our data suggest an important role of MTHFR gene variants in SPD.
keywords:

rs1801133, MTHFR, Parkinson’s disease, common variants, C677T, Mexico

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