eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
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SCImago Journal & Country Rank
4/2010
vol. 48
 
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abstract:

Original paper
Calf thymus extract attenuates severity of experimental encephalomyelitis in Lewis rats

Michał Zimecki
,
Jolanta Artym
,
Maja Kocięba
,
Jan Kuryszko
,
Katarzyna Kaleta-Kuratewicz
,
Krzysztof Marycz

Folia Neuropathol 2010; 48 (4): 246-257
Online publish date: 2010/12/17
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The aim of this study was to evaluate the efficacy of treatment of Lewis rats with calf thymus extract (TFX®) and its six-peptide fraction on the course of experimental allergic encephalomyelitis (EAE). Interferon- ß served as a reference drug. We found that intramuscular administration of the thymus extract fraction significantly reduced clinical, immunological, histological, and ultrastructural alterations inherent in the disease. We suggest that TFX® or TFX®-derived fractions have potential as therapeutics in treatment of neurodegenerative diseases such as multiple sclerosis.
keywords:

EAE, Lewis rats, TFX®, IFN-ß

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