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Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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vol. 31

Original paper
Dermoscopy of accessory nipples in authors’ own study

Grażyna Kamińska-Winciorek
Jan Szymszal
Wojciech Silny

Postep Derm Alergol 2014; XXXI, 3: 127–133
Online publish date: 2014/06/13
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The mammary gland of an adult individual is situated on the level of the second to sixth or seventh costae, in a transverse direction towards the parasternal line, ending in the vicinity of the central axillary line [1]. Apart from the two typical mammary glands found among individuals of both genders, albeit more often among women, what is known as the mammae accesoriae, or an accessory gland, may at times be observed. There are also occurrences of an additional nipple appearing, devoid of any glands (hyperthelia). This is more commonly observed among men [1]. The frequency of the occurrence of the accessory nipple (AN) is at 1% to 2% [2]. This additional or supernumerary nipple is typically situated approximately 10 cm below the main nipple, and is somewhat more centrally placed on the abdomen. This nipple is usually much smaller in size and typically devoid of an areola [1] (Figure 1). The classic dermoscopic image of the normal nipple has been shown in Figure 2. Dermoscopic pictures of AN in 1 patient are presented in Figures 3 and 4.
Usually, supernumerary nipples develop along the two vertical ‘milk lines’ which start in the armpit on each side, run down through the standard nipple, and end at the groin [1–3]. Worldwide, only 2 cases of patients with a total of seven additional nipples have been documented [3]. The classification of the supernumerary nipple includes 8 different clinical types, according to Kajava [4]. This matter has been extensively described in the latest report published by Goyal et al. [3].
In some cases, AN (the supernumerary nipple) clinically suggest either dermatofibroma, fibroma or the presence of the melanocytic nevi [5]. The ability of recognising the AN as a potential underlying internal malignancy such as seminoma [6], renal adenocarcinoma [7] and also, potentially, breast cancer [8], melanoma [9] or Paget’s disease [10] developing within this lesion, is absolutely crucial. Recognition of this AN as a genodermatosis with malignant potential is extremely important in all medical specialisations, such as oncology, surgery, primary care, gynaecology, dermatology and geriatrics. Therefore, the knowledge of clinical and dermoscopic recognition of the AN is a clue in the diagnostic algorithm and in the differential diagnosis of melanocytic and non-melanocytic lesions.


The aim of the study is to describe the most commonly occurring dermoscopic features of the AN, with their clinical manifestations. The recognition of the clinical and dermoscopic features will be helpful for doctors in consecutive diagnostic procedures.

Material and methods

Fourteen patients (7 males, 7 females) of an average age of 32 (the median age was 29.2, with a minimum of 14 years and a maximum of 54, SD 13.1 years) were diagnosed clinically and dermoscopically with a condition known as the AN during routine dermatologic examinations in the Private Dermatological Unit between January 2008 and January 2014. The total number of analysed dermoscopic pictures of all AN lesions was 19. The recognition of the AN was based on clinical imaging and on a palpable dimpling or tip manifested in changes located characteristically in the region where an AN might be found, as presented in the introduction.
Every AN was checked with a hand-held Delta 20 Heine dermoscope and recorded in the form of captured clinical and dermoscopic digital images with the help of the FotoFinder Dermoscope Dynamic Medicam 800 HD software (FotoFinder Systems GmbH). The recorded images were analysed retrospectively according to the procedure presented below.
All AN were described clinically and dermoscopically, taking into account their location and their overall dermoscopic pattern.
Images of all the AN were analysed according to basic dermoscopic features proposed by previous authors [5, 11–13] and according to our own additional criteria (Table 1):
1. Peripheral network (network-like structures),
2. Central network-like structures,
3. Central white scar-like area,
4. Cleft-like appearance,
5. White cobblestone-like structures,
6. Central round dimpling with a plug,
7. Fisheye-like structures resembling comedo-like openings.
Moreover, new dermoscopic findings observed in the course of our own research are presented in the results section.

Statistical analysis

A statistical assessment was made and implemented with the help of the Statistica StatSoft version V 7.1 PL statistic software. In this statistical analysis, the statistical level was p < 0.05. The non-parametric Fisher’s exact test was used in the statistical assessment in nominal scale. In order to compare quantitative characteristics, the parametric t Student test was also adopted.


Characteristics of the investigated patients’ group

In the t Student test, the investigated patients’ group of females and males was homogeneous as regards the age criterion (p = 0.236). The average age for females was 36 (min. 19, max. 54 years, SD 13.3). The average age for men was 27.7 years (min. 14, max. 48, the median being 23 years, SD 12.3).

Clinical presentation of accessory nipples

The total number of bilateral nipples was 8 lesions in 4 patients. Symmetrical manifestation of the AN was observed in 2 patients with bilateral nipples (total number of AN was 4).
The unilateral clinical presentation consisted of a group of patients who were diagnosed with 9 left-sided lesions in 8 patients and 2 right-sided lesions in 2 patients.
Clinically, the AN occurred as a solitary papule in 6 le­sions (in 6 patients) and as a nodule in 8 AN in 7 patients. An additional areola was present with nodules in 2 lesions (2 patients). More rare clinical representations of the AN included patch hair in 1 lesion, a macule in 5 instances of the AN (in 5 patients) and a dimpling in 7 lesions (in 6 patients).

Dermoscopy of the accessory nipples

The dermoscopic findings concerning AN are presented in Table 2 and Figures 5–10. In the case of the absence of central white scar-like areas, a central network-like structure is always present (4/19 lesions). If the central white scar-like area is present (15 lesions), then central network-like structures appear in only 20% of subjects (3/19 lesions) (Fisher’s exact test p = 0.0091).
White cobblestone-like structures (7/19 lesions) were also present, with central network-like structures in 5/19 lesions (72%) (Fisher’s exact test p = 0.0449). There is no statistical significance between the occurrence of the cleft-like appearance and central network-like structures (p = 0.3765).
Statistical significance exists between the presence of the central round dimpling and central network-like structures. The occurrence of the central round dimpling never appears alongside central network-like structures in any of the analysed lesions (Fisher’s exact test p = 0.0436). There is no statistical significance between the presence of central network-like structures and fisheye-like structures (p = 0.7366).
The presence of peripheral network-like structures with the occurrence of central scar-like patterns is statistically highly significant (Fisher’s exact test p = 0.0091). Central scar-like areas (15/19 lesions) always occurred in the company of peripheral network-like structures (12/19, 80%).
The presence of peripheral network-like structures (12/19) rather excludes the occurrence of white cobblestone-like structures (10 out of 19 lesions were devoid of this dermoscopic feature) (p = 0.0499). There is no statistical significance between the presence of peripheral network-like structures and the cleft-like appearance (p = 0.3765).
The coincidental occurrence of peripheral network-like structures with the central round dimpling is statistically significant. In all the cases of the central round dimpling (6/19 lesions), peripheral network-like structures had always been present (p = 0.0436). There is no significant statistical link between peripheral network-like structures and fisheye-like structures (p = 0.7633).
There is no significant statistical link between central scar-like area and the white cobblestone pattern (p = 0.6026). This also applies to the central scar-like area and cleft-like appearance (p = 0.6026) and to the central scar-like area and central round dimpling (p = 0.2554). However, in all cases of the central round dimpling, the occurrence of the central scar-like area had been observed (6/19 lesions). There is no statistical significance between the central scar-like area and fisheye-like structures (p = 0.9056).
White cobblestone-like structures with a cleft-like appearance bore no statistical significance (p = 0.0674), however, it should be highlighted that in 19 lesions of AN, both white cobblestone and cleft-like structures were absent (11/19 and 9/19, respectively).
The occurrence of the white cobblestone pattern with a central round dimpling was without any statistical significance (p = 0.3331). In 6 out of 19 lesions, the presence of a round central dimpling with a plug (84%) was linked with as many as 5 lesions manifesting the absence of the white cobblestone. There is no statistical significance between fisheye-like and white cobblestone-like structures (p = 0.7633).
The presence of the central round dimpling excludes the occurrence of the cleft-like appearance in all lesions (6/19) (p = 0.0118). The occurrence of fisheye-like structures (9/19) in as many as 7 lesions manifested the absence of the cleft-like pattern (78%) (p = 0.1698). There is no statistical significance between fisheye-like structures and the central round dimpling (p = 0.3498).
The frequency of the occurrence of selected analysed dermoscopic features in the absence of central network-like structures is illustrated in Figure 11 and their frequency in the absence of peripheral network-like structures is described in Figure 12.


The AN is one of extremely rare dermatological conditions. Its frequency amongst the population ranges between 1% and 2% [2]. The dermoscopic characteristics of the AN which have already been defined are: the presence of structures resembling a pigment network (network-like structures) as well as a central white-scar area [5, 11–14]. In our own study, the peripheral network (network-like structures) proved to be present in a total of 79% of the described changes. The pigment network usually pointed out to a melanocytic character of the changes, according to the algorithm for the differentiation for melanocytic lesions [5]. The pigment network which may at times appear in cases of the AN is in itself an exception in accordance with the algorithm for the differentiation of melanocytic changes. This is due to the fact that it concerns a non-melanocytic change in this type of condition, which is a group to which the AN belongs.
Dermatofibroma is the second exception among the changes characterised by the appearance of a pigment network. This is not classed as a melanocytic lesion, either [5, 11, 12, 15]. Moreover, the presence of central scar-like area within the dermatofibroma [15] may also be the basis for incorrect recognition in comparison with the AN [14]. In both exceptions mentioned above, the finding of the pigment network may lead to the erroneous diagnosis of a melanocytic change, which could lead to an unnecessary excision of the diagnosed lesion.
During observations carried out by Zaballos et al. [16] concerning 412 dermatofibromas, a pigment network were observed in 71% of lesions and white scar-like areas were noted in a total of 57% of lesions [16]. What is more, the presence of white scar-like areas should always suggest the necessity of ruling out melanoma through a dermoscopic examination – especially its desmoplastic type [17] or the fully regressive melanoma [18]. Scar-like white areas are a usual histological suggestion of fibrosis [3].
The dermoscopic pattern of AN has, until recently, been most commonly described as a peripheral network-like structures [19], as was also the case with central scar-like areas; characteristics of these all belong to the standard dermoscopic features of the AN. Also, the statistical significance of the appearance of the central scar-like area (63%), as well as of peripheral network-like structures found in 79% of the analysed lesions has been proven for both of the above characteristics in the course of our own study. To sum up, network-like structures in their central location (7/12) or those placed peripherally (12/12) were found in 100% of the presented cases of the AN.
The new terminology used to describe dermoscopic features found within the AN as that of a white cobblestone-like structure is presented by the authors for the first time in this study. The image does, in fact, in its appearance resemble the previously described classic elevated cobblestone pattern formed by cobblestoned surfaces [11, 12, 20]. This commonly concerns the melanocytic congenital nevi [20]. The cases which the authors have described in the paper were statistically significantly afflicted with such white cobblestone-like structures, along with central network-like structures, which, in a unique way, separated the white, slightly elevated areas of the skin changes, dividing them into structures resembling cobblestones, which commonly appear in the classic dermoscopic cobblestone pattern.
In Oztas’ study [13] concerning 5 cases of the solitary occurrence of the AN, an additional dermoscopic structure was described, referred to as the cleft-like appearance. According to Oztas et al. [13], especially if the central cleft can be demonstrated using dermoscopy, the diagnosis can easily be made, especially in relation to differentiating the condition against dermatofibroma [13]. According to our observations, the cleft-like appearance concerned 42% of lesions, whereas its presence in all the examined AN was ruled out by the presence of a central round dimpling (31%). It may thus be summarised on the basis of the conducted dermoscopic analysis that the AN may manifest itself through its cleft-like appearance or through a central round dimpling. The presence of either one of these features was observed in as many as 73% of lesions. Moreover, peripheral network-like structures were present in all the cases in which we described the central round dimpling.
Fisheye-like structures resembling comedo-like openings were present in 47% of AN. These are most probably formed of hyperkeratotic masses located within the indentation of the AN. Typically comedo-like openings are most commonly found in seborrheic keratosis and in the dermal nevi, usually of their exophytic type [11, 12, 21].
The knowledge of dermoscopic features concerning skin cancer and melanoma in its early stages [22, 23], and also of rare dermatological disorders, such as the AN and the nevus comedonicus [24] is extremely useful in daily medical practice. 


The conducted dermoscopic analysis of a total of 19 AN confirmed the presence of a pigment network in all the examined lesions (central or peripheral network-like structures), with the peripheral type being the most commonly observed. Also, peripheral network-like structures with the occurrence of a central scar-like area have been most commonly presented in our study. The appearance of the central network-like structures usually meant the presence of white cobblestone-structures in the dermoscopic images of AN. The new dermoscopic structures present in AN were as follows: a central round dimpling with a plug and fisheye-like structures resembling comedo-like openings.

Conflict of interest

Authors declare no potential conflict of interest. Funding sources: none.


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