en POLSKI
eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank


 
5/2008
vol. 46
 
Share:
Share:
more
 
 
abstract:

Original paper
HLA class I and II associations with systemic onset juvenile idiopathic arthritis

Elżbieta Musiej-Nowakowska
,
Barbara Mączyńska-Rusiniak

Reumatologia 2008; 46, 5: 266–271
Online publish date: 2008/12/01
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Systemic onset JIA is dramatically different from the other forms of JIA clinically. While HLA associations are a significant genetic factor in most of the JIA subtypes, there are few or no associations with systemic JIA. We studied the frequencies of class I and II antigens in 47 Polish patients (8-35 years old) with systemic onset JIA. The mean age of onset was 4.5±3 years (range 7 months – 11 years). The mean disease duration was 18±7.4 years. When the antigen frequencies for JIA patients were compared to a normal control population, significantly higher frequencies of B27, DR4 and DR3 antigens were found, while the frequencies of DR6 were lower. This study confirms previous reports of an increased incidence of DR4 and HLA B27 in these patients and suggests an association of DR3 with systemic onset JIA in the Polish population.
keywords:

systemic onset juvenile idiopathic arthritis, HLA class I and II, genetic associations, DR4, DR3







Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.