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ISSN: 1233-9687
Polish Journal of Pathology
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3/2014
vol. 65
 
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abstract:

Original paper
Inverse correlation of phospho-KDR/Flk-1 expression and stage of colorectal cancer: implication of the significance of neoangiogenesis in activated VEGFR-2 expressing early stage colorectal adenocarcinomas

Yi-Feng Lin
,
Chun-Chao Chang
,
Shu-Hui Lin
,
Chung-Min Yeh
,
Tzu-Cheng Su
,
Pei-Ru Wu
,
Kun-Tu Yeh
,
Ming-Chung Jiang
,
Pi-Yu Chen
,
Hui-Ting Hsu

Pol J Pathol 2014; 65 (3): 194-201
DOI: https://doi.org/10.5114/pjp.2014.45781
Online publish date: 2014/10/18
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The activation of vascular endothelial cell growth factor receptors (VEGFRs) plays an essential role in cancer progression. In this study, we investigated the expression of phosphorylated VEGFR-2 (or phospho-KDR/Flk-1), the activated form of VEGFR-2, in human colorectal adenomas and colorectal adenocarcinomas. Phospho-KDR/Flk-1 showed weak expression in the normal colorectal tissue. Phospho-KDR/Flk-1 was mainly stained in the cytoplasm of colorectal adenomas, and was stained in both the cytoplasm and nuclei colorectal adenocarcinomas. There was no indication of increased phospho-KDR/Flk-1 expression in the colorectal adenocarcinomas, as compared to that of colorectal adenomas. Furthermore, there was an inverse relationship of phospho-KDR/Flk-1 expression with cancer stage (p < 0.0001), lymph node metastasis (p = 0.011), and distant metastasis (p = 0.021) of the colorectal adenocarcinomas. Our results indicate that early stage colorectal adenocarcinomas with highly activated (phosphorylated) VEGFR-2 expression may indicate the significance of neoangiogenesis of the tumors.
keywords:

cancer stage, colorectal adenocarcinoma, metastasis, phospho-KDR/Flk-1, VEGFR-2
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