eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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abstract:
Original paper

Overexpression of kif11 is a poo r prognostic factor in clear cell renal cell carcinoma

Adam Michał Kowalewski
1, 2
,
Damian Jaworski
3
,
Paulina Antosik
1
,
Marta Smolińska
1
,
Joanna Ligmanowska
1
,
Dariusz Grzanka
1
,
Łukasz Szylberg
2, 4

1.
Chair and Department of Clinical Pathomorphology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
2.
Department of Tumor Pathology and Pathomorphology, Oncology Centre – Prof. Franciszek £ukaszczyk Memorial Hospital, Bydgoszcz, Poland
3.
Division of Ophthalmology and Optometry, Department of Ophthalmology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
4.
Department of Perinatology, Gynaecology and Gynaecologic Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
Pol J Pathol 2022; 74 (2)
Online publish date: 2022/07/15
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Introduction
Unresectable renal cell carcinoma continues to be a great challenge due to our limited understanding of its underlying pathophysiology. We explored the relationship between KIF11 protein expression and the clinical courses of clear cell renal cell carcinoma (ccRCC) using a tissue microarray.

Material and methods
The tissue microarray contained specimens derived from 90 patients, cancer and matched adjacent non-cancerous tissue (2 cores per case), followed up for 7 years. Tumour samples were evaluated for KIF11 expression using the H-score, and their correlations with clinicopathological data and survival data were analysed.

Results
72.7% of ccRCC tissues presented KIF11 cytoplasmic expression with a median value of 20 (interquartile range 0–200). The nuclear staining was positive in 36.36% of ccRCC tissues. Among controls, nuclear KIF11 expression was absent, but cytoplasmic expression was identified in all cases, with a median value of 230 (interquartile range 45–290). Cytoplasmic KIF11 expression in ccRCC tissues was lower than in the control tissues and was positively correlated with tumour grade and mortality (p < 0.05). KIF11 nuclear expression did not correlate with overall survival.

Conclusions
Elevated expression of KIF11 predicts poor clinical outcome in ccRCC patients. Downregulation of KIF11 may provide a new therapeutic strategy for ccRCC.

keywords:

KIF11, ccRCC, kidney cancer, renal carcinoma, expression, prognosis, survival, OS

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