P2X7 GENE POLYMORPHISMS AND PULMONARY TUBERCULOSIS SUSCEPTIBILITY: A GLOBAL SYSTEMATIC REVIEW

Several studies have recently demonstrated the roles of purinergic receptor P2X ligand-gated ion channel 7 (P2X7) polymorphisms in pulmonary tuberculosis, yet these were controversial and inconclusive (inconsistent). Thus, the present study was designed to systematically assess the relationship between P2X7 gene polymorphisms and pulmonary tuberculosis susceptibility. Eligible studies were searched through the PubMed, Web of Science, Semantic Scholar, Elsevier and Google Scholar databases until 2024. The systematic review was performed according to the PRISMA guidelines. The review of literature included 20 case-control, pilot, and meta-analysis studies on pulmonary tuberculosis that included a total of 50,359 cases and 57,375 controls. The particular studies included in this review were conducted between 2014 and 2024, shortlisted during the current study to investigate the association of P2X7 gene polymorphisms with susceptibility to tuberculosis infection. The knowledge of the impact of P2X7 gene polymorphisms on susceptibility to pulmonary tuberculosis is relevant for better management of this disease and for determining the most appropriate therapy.