An 18-year-old female student presented to us with a history of episodes of nocturnal shortness of breath, precipitated on exposure to cold, for a duration of 6 years. Suspecting it to be due to bronchial asthma, the patient was subjected to spirometry. Pre-bronchodilator spirometry revealed abnormal pulmonary function, suggestive of obstructive lung disease. Postbronchodilator spirometry with a salbutamol metered-dose inhaler (MDI) showed a further decrease in pulmonary function, suggestive of bronchoconstriction. In such cases, it may lead to an erroneous diagnosis of chronic obstructive pulmonary disease or an inappropriate clinical response, leading to therapeutic implications. Here we report a case of a bronchial asthma patient showing paradoxical bronchoconstriction following use of a salbutamol metered-dose inhaler.