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Alergologia Polska - Polish Journal of Allergology
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1/2023
vol. 10
 
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abstract:
Review paper

Participation of reactive oxygen species in the pathogenesis of atopic dermatitis, allergic rhinitis and asthma

Magdalena Skalska
1
,
Paulina Kleniewska
1
,
Rafał Pawliczak
1

  1. Department of Immunopathology, Faculty of Medicine, Medical University of Lodz, Lodz, Poland
Alergologia Polska – Polish Journal of Allergology 2023; 10, 1: 26–31
DOI: https://doi.org/10.5114/pja.2023.125765
Online publish date: 2023/03/14
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Reactive oxygen species (ROS) are any usually highly reactive chemical compounds that contain an oxygen atom with an unpaired electron in their structure. In physiological conditions, they are involved in many metabolic reactions in the body, while they are also involved in the pathogenesis of diseases such as atopic dermatitis, allergic rhinitis and asthma. Excessive ROS and antioxidant barrier dysfunction cause oxidative stress, resulting in increased oxidative damage in cells, disruption of their proper functioning and induction of a chronic inflammatory process.
keywords:

atopic dermatitis, allergic rhinitis, asthma, reactive oxygen species



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