Over 235 million people struggle with asthma. Many patients suffering from a severe type of asthma have a problem with disease control. In this case, basic treatment like high-dose inhaled corticosteroids may not have a suitable effect. With the present level of knowledge about phenotypes and endotypes of asthma, there is a way to customise a more personalised and effective type of medication for every patient. Omalizumab was the first novel type of therapy, and almost 20 years since its approval, it is still one of the most commonly prescribed biologics for asthma treatment. Now, new types of innovating biologics are being invented. This overview presents drugs that are being investigated for treatment or have already been approved.