Position statement of the HAE Section of the Polish
Society of Allergology on the management of hereditary
angioedema due to C1 inhibitor deficiency: 2025 update.
Part II: treatment, monitoring, perioperative management,
and the particular aspects of care for women and children

Grzegorz Porębski; Aleksandra Kucharczyk; Tomasz Matuszewski; Hanna Danielewicz; Jacek Gocki; Katarzyna Grzela; Aldona Juchacz; Marcin Kurowski; Krzysztof Kuziemski; Mateusz Łukaszyk; Małgorzata Sokołowska; Marcin Stobiecki; Ewa Trębas-Pietraś; Marta Tykwińska; Ewa Czarnobilska; Marcin Moniuszko; Krystyna Obtułowicz

doi:10.5114/pja.2025.156375

eISSN: 2391-6052
ISSN: 2353-3854

Alergologia Polska - Polish Journal of Allergology

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Position statement of the HAE Section of the Polish Society of Allergology on the management of hereditary angioedema due to C1 inhibitor deficiency: 2025 update. Part II: treatment, monitoring, perioperative management, and the particular aspects of care for women and children

Grzegorz Porębski

¹

,

Aleksandra Kucharczyk

²

,

Tomasz Matuszewski

²

,

Hanna Danielewicz

³

,

Jacek Gocki

⁴

,

Katarzyna Grzela

⁵

,

Aldona Juchacz

⁶

,

Marcin Kurowski

⁷

,

Krzysztof Kuziemski

⁸

,

Mateusz Łukaszyk

⁹

,

Małgorzata Sokołowska

¹⁰

,

Marcin Stobiecki

¹

,

Ewa Trębas-Pietraś

¹¹

,

Marta Tykwińska

¹²

,

Ewa Czarnobilska

¹

,

Marcin Moniuszko

¹³

,

Krystyna Obtułowicz

¹

Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland
Department of Internal Diseases, Pneumonology, Allergology, Clinical Immunology and Rare Diseases, Military Institute of Medicine – National Research Institute, Warsaw, Poland
1st Clinical Department of Pediatrics, Allergology and Cardiology, Wroclaw Medical University, Wroclaw, Poland
ALERGODERM, Specialist Medical Practice, Bydgoszcz, Poland
Department of Pediatric Pneumonology and Allergy, Medical University of Warsaw, Poland
Greater Poland Center of Pulmonology and Thoracic Surgery, Poznan, Poland
Department of Immunology and Allergy, Central Teaching Hospital of the Medical University of Lodz, Poland
Department of Pulmonology and Allergology, Faculty of Medicine, Medical University of Gdansk, Poland
1st Department of Lung Diseases and Tuberculosis, Medical University of Bialystok, Poland
Independent Public Clinical Hospital No. 2, Pomeranian Medical University, Szczecin, Poland
Department of Allergology and Lung Diseases, Cardinal Wyszyński Provincial Specialist Hospital SPZOZ, Lublin, Poland
Department of Allergology, Clinical Immunology and Internal Medicine, University Hospital No. 2, Bydgoszcz, Poland
Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland

Alergologia Polska – Polish Journal of Allergology 2025; 12, 4: 233–249

DOI: https://doi.org/10.5114/pja.2025.156375

Data publikacji online: 2025/11/21

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AMA

Porębski G, Kucharczyk A, Matuszewski T, et al. Position statement of the HAE Section of the Polish
Society of Allergology on the management of hereditary
angioedema due to C1 inhibitor deficiency: 2025 update.
Part II: treatment, monitoring, perioperative management,
and the particular aspects of care for women and children. Alergologia Polska - Polish Journal of Allergology. 2025;12(4):233-249. doi:10.5114/pja.2025.156375.

APA

Porębski, G., Kucharczyk, A., Matuszewski, T., Danielewicz, H., Gocki, J.,  & Grzela, K. et al. (2025). Position statement of the HAE Section of the Polish
Society of Allergology on the management of hereditary
angioedema due to C1 inhibitor deficiency: 2025 update.
Part II: treatment, monitoring, perioperative management,
and the particular aspects of care for women and children. Alergologia Polska - Polish Journal of Allergology, 12(4), 233-249. https://doi.org/10.5114/pja.2025.156375

Chicago

Porębski, Grzegorz, Aleksandra Kucharczyk, Tomasz Matuszewski, Hanna Danielewicz, Jacek Gocki, Katarzyna Grzela,  and Aldona Juchacz et al. 2025. "Position statement of the HAE Section of the Polish
Society of Allergology on the management of hereditary
angioedema due to C1 inhibitor deficiency: 2025 update.
Part II: treatment, monitoring, perioperative management,
and the particular aspects of care for women and children". Alergologia Polska - Polish Journal of Allergology 12 (4): 233-249. doi:10.5114/pja.2025.156375.

Harvard

Porębski, G., Kucharczyk, A., Matuszewski, T., Danielewicz, H., Gocki, J., Grzela, K., Juchacz, A., Kurowski, M., Kuziemski, K., Łukaszyk, M., Sokołowska, M., Stobiecki, M., Trębas-Pietraś, E., Tykwińska, M., Czarnobilska, E., Moniuszko, M.,  and Obtułowicz, K. (2025). Position statement of the HAE Section of the Polish
Society of Allergology on the management of hereditary
angioedema due to C1 inhibitor deficiency: 2025 update.
Part II: treatment, monitoring, perioperative management,
and the particular aspects of care for women and children. Alergologia Polska - Polish Journal of Allergology, 12(4), pp.233-249. https://doi.org/10.5114/pja.2025.156375

MLA

Porębski, Grzegorz et al. "Position statement of the HAE Section of the Polish
Society of Allergology on the management of hereditary
angioedema due to C1 inhibitor deficiency: 2025 update.
Part II: treatment, monitoring, perioperative management,
and the particular aspects of care for women and children." Alergologia Polska - Polish Journal of Allergology, vol. 12, no. 4, 2025, pp. 233-249. doi:10.5114/pja.2025.156375.

Vancouver

Porębski G, Kucharczyk A, Matuszewski T, Danielewicz H, Gocki J, Grzela K et al. Position statement of the HAE Section of the Polish
Society of Allergology on the management of hereditary
angioedema due to C1 inhibitor deficiency: 2025 update.
Part II: treatment, monitoring, perioperative management,
and the particular aspects of care for women and children. Alergologia Polska - Polish Journal of Allergology. 2025;12(4):233-249. doi:10.5114/pja.2025.156375.

Metryki PlumX:

The second part of the updated guidelines focuses on the treatment of hereditary angioedema with C1 inhibitor deficiency (HAE-C1INH), as well as the specific clinical presentation and management of HAE in special populations, particularly women and children. This section also emphasizes the importance of patient education and appropriate disease monitoring throughout the course of therapy. One of the most significant developments in recent years has been the evolution of long-term prophylaxis (LTP). Several new agents have been approved for use, showing high efficacy in reducing the frequency and severity of attacks, while also contributing to the normalization of patients’ daily functioning and quality of life – all with a favorable safety profile. As a result, a growing number of patients are being successfully managed with LTP. Furthermore, this section elaborates on recommendations for short-term prophylaxis and perioperative management. Since the effectiveness and safety of therapy are closely linked to patient adherence, the guidelines also address home treatment protocols, structured monitoring strategies, and the organization of comprehensive patient care in Poland.