eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
1/2021
vol. 72
 
Share:
Share:
more
 
 
Case report

Primary anaplastic large T-cell lymphoma of the psoas muscle

Irene Pecorella
1
,
Angela Ferrari
1
,
Andrea Tornese
1
,
Quirino Lai
2
,
Gianluca Mennini
2
,
Massimo Rossi
2

1.
Department of Radiological, Oncological and Anatomic Pathology Sciences
2.
Department of General and Specialistic Surgery “P. Stefanini”, Hepato-Biliary Surgery and Organ Transplantation Unit, University of Rome “La Sapienza”, Rome, Italy
Pol J Pathol 2021; 72 (1): 89-96
Online publish date: 2021/05/31
Article file
- 11-PJP-01917.pdf  [3.79 MB]
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
 
Solution to quiz

The histological findings are consistent with a skeletal primary anaplastic large cell lymphoma (ALCL), ALK-1+. Our patient underwent extensive hematologic and radiological diagnostic workup, which failed to show further site involvement. Bone marrow aspiration revealed normocellular marrow (50%) with adequate trilineage hematopoiesis, and no evidence of lymphoma, immunoglobulin heavy chain gene rearrangements, or immunoglobulin kappa light chain gene rearrangements. Aggressive adjuvant chemotherapy based on 6 cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) scheme was started. The patient achieved complete response and the follow-up PET scans up to two years postchemotherapy treatment showed no evidence of recurrence. He is presently disease free, at 28 months following diagnosis.

Commentary

Anaplastic large cell lymphoma is a rare lymphoproliferative T-cell disorder, which accounts for 2-3% of non-Hodgkin’s lymphomas (NHL) of the adult. It is relatively more common in the first three decades of life, particularly in childhood, where it accounts for up to 20% of NHL. It usually arises from lymph nodes, while primary extranodal locations are considered to be extremely rare. Skeletal muscle involvement by lymphoma is unusual, most often occurring as a result of hematogenous or lymphatic spread or contiguous spread from adjacent involved lymph nodes or bone [1]. The most commonly affected muscles are those of the extremities, pelvis, and gluteal regions. Lymphomatous involvement of muscles has been reported to occur in 0.3% of Hodgkin lymphoma and 1.1% of NHL (overall, 1.4% of cases) [1]. Primary skeletal muscle NHL (PSM-NHL) is an even rarer disease, accounting for only 0.5% of all extranodal lymphomas [2]. Using very stringent criteria in the selection of cases, Travis and coll demontrated that PSM-NHL accounted for only 0.11% of all lymphomas diagnosed at Mayo Clinic in a 10-year period of time [3].
An increased frequency of PSM-NHL (7%) is detected among AIDS-associated lymphomas [4]. The definition of primary extranodal lymphoma is controversial. Currently, an accepted definition is no or only minor nodal involvement associated with a clinically dominant extranodal component [5]. We reviewed the scientific literature for PSM-NHL. We chose to exclude cases of concurrent nodal, visceral or systemic disease, as well as instances with apparent direct extension from primary lymphoma of the bone on CT scans at presentation. In the selected published cases, diffuse lymphoma had been ruled out by CT of the thorax and abdomen, marrow aspirate, or at least 3-month follow-up reports. Cases with initial evaluation, not extensive enough to reasonably exclude disseminated disease were also discarded, as well as case series with no data on single patients. Using these inclusion criteria, our literature searches for PSM-NHL retrieved only 7 primary muscle ALCL and 51 other lymphomas (Table I).
Data show that PSM-NHL most commonly affects muscles of the lower extremities and pelvic region of elderly patients (6/8 ALCL; 32/51 other primary skeletal lymphomas; Table I). It usually presents as a localised mass [6], though cellulitis-like manifestations can be observed when involvement of the skin is present [7, 8]. Lymphoma may involve all or part of individual muscles and different degrees of involvement may be seen in different muscles in the same patient [9, 10]. A majority of patients show stranding in the subcutaneous fat, with a minority demonstrating overlying skin thickening. The age range is rather wide (6 to 93 years; mean 57.4 years), although PSM-ALCL included a younger patients’population (mean age 35,2 years vs. 60.8 years; Table I).
The present case illustrates a CD30+, ALK-1+, ALCL in the psoas muscle of an adult patient. Other subtypes include diffuse large B-cell lymphoma, peripheral T-cell lymphoma, natural killer T-cell lymphoma nasal type, follicular lymphoma and Burkitt lymphoma (Table I) [6]. Most reported cases (> 95%) are B-cell lymphomas, while our case was of T-cell lineage. In Chim’s series of 17 cases of NHL with skeletal muscle involvement, 16 were of B-cell lineage and only 1 was an ALCL [11]. Overall, only few cases of PSM-ALCL have so far been described, and 62.5% of them arose in the first three decades of life (Table I). ALCL, also known as Ki-1 (CD30+) lymphoma, is a non-Hodgkin lymphoma of T-cell origin, less often of null-cells type (younger presentation). It is predominantly an activated CD4+ T-cell tumor with an unusual cytotoxic TIA-1+, granzyme B+, perforin+, granulysin+, EMA+, punctate cytoplasmic clusterin+ phenotype. It frequently involves both lymph nodes and extranodal sites. The most common extranodal sites are skin, bone, soft tissues, lung and liver. Orbital, gastrointestinal and CNS involvement is occasionally seen. Marrow involvement is observed in 10% to 30% of cases [12]. Our case is peculiar in that no nodal involvement was present, and the mass appeared to arise within the psoas muscle. PSM-ALCL has also been described in dogs [13]. Three morphologic variants have been recognized: common, lymphohistiocytic, and small cell variant, all variants showing “hallmark” cells with eccentric horseshoe-shaped nuclei and an eosinophilic dense paranuclear region. Our case was of the common histological type.
Anaplastic large cell lymphoma is not EBV related, but can be associated with HIV, mycosis fungoides, pulmonary inflammatory pseudotumors. A subgroup of ALCL is characterized by recurrent t(2;5)(p23;q35) translocation, leading to the formation of a NPM-ALK fusion protein with proven oncogenic capacity. ALK-1+ ALCL is a clinically aggressive lymphoma that mostly occurs in young males [12], and carries a better prognosis than the negative ones after treatment with aggressive chemotherapy, with a 5-year survival as high as 80-90% [14]. So far no recurrent cytogenetic alterations have been described in ALK-1 negative ALCL. Fortunately, the present case showed immunohistochemical positivity for ALK protein expression, and responded well to adjuvant chemotherapy.
Clinically, the most common presenting symptom is local pain, associated with a slow-growing or fast growing mass, or diffuse enlargement of the affected muscle. Lim et al. suggested that MRI is the most useful modality for assessment of muscular lymphoma, and the tumor will appear homogeneous and isointense to muscle signal on T1-weighted images, and diffusely hyperintense on T2 weighted images [15]. However, differentiation of skeletal muscle lymphoma from various neoplastic and inflammatory diseases is often difficult on the basis of clinical and imaging findings alone. On CT the masses can either be hypodense or isodense to normal muscle tissue, leading to confusion with muscle sarcomas. However, avid enhancement appears to be a universal feature [9]. Tumor biopsies are essential for definite diagnosis. The treatment response and the prognosis of patients with PML are difficult to determine because of the low number of published cases and the lack of follow-up data. Our literature review shows that the three ALCL ALK+ patients were disease free at long-term follow-up (Table I).
In conclusion, although a rare tumor, primary skeletal muscle lymphoma should be considered in the differential diagnosis of a bulky skeletal muscle mass. As imaging cannot definitively establish the diagnosis of primary muscle lymphoma, a tissue biopsy with histological examination is required. When biopsy specimens are too difficult to acquire, fine-needle aspiration cytology becomes an acceptable alternative diagnostic procedure. Early recognition and correct diagnosis will allow the proper treatment protocol to be initiated.
The authors declare no conflict of interest.

References

1. Alamdari A, Naderi N, Peiman S, Shahi F. Non-Hodgkin lymphoma with primary involvement of skeletal muscle. Int J Hematol Oncol Stem Cell Res 2014; 8: 55-57.
2. O’Neill JK, Devaraj V, Silver DA, et al. Extranodal lymphomas are presenting as soft tissue sarcomas to a sarcoma service over a two-year period. J Plast Reconstr Aesthet Surg 2007; 60: 646-654.
3. Travis WD, Banks PM, Reiman HM. Primary extranodal soft tissue lymphoma of the extremities. Am J Surg Pathol 1987; 11: 359-366.
4. Raphael M, Gentilhomme O, Tulliez M, et al. Histopathologic features of highgrade nonHodgkin’s lymphomas in acquired immunodeficiency syndrome. The French study group of pathology for human immunodeficiency virusassociated tumors. Arch Pathol Lab Med 1991; 115: 15-20.
5. Burton E, Schafernak K, Morgan E, Samet J. Skeletal muscle involvement in B-Cell Lymphoma: two cases illustrating the contribution of imaging to a clinically unsuspected diagnosis. Case Rep Radiol 2017; 2017: 2068957.
6. Chun CW, Jee WH,.Parketal HJ. MRI features of skeletal muscle lymphoma. Am J Roentgenol, 2010; 195: 1355-1360.
7. Baddour LM, Haden KH, Allen JW. Primary skeletal muscle lymphoma presenting as refractory cellulitis. Cutis 2001; 68: 223-226.
8. Kandel RA, Bédard YC, Pritzker KP, Luk SC. Lymphoma. Presenting as an intramuscular small cell malignant tumor. Cancer; 1984; 53: 1586-1589.
9. Beggs I. Primary muscle lymphoma. Clin Radiol 1997; 52: 203-212.
10. Suresh S, Saifuddin A, O’Donnel P. Lymphoma presenting as a musculoskeletal soft tissue mass: MR findings in 24 cases. Eur Radiol 2008; 18: 2628-2634.
11. Chim CS, Choy C, Liang R. Primary anaplastic large cell lymphoma of skeletal muscle presenting with compartment syndrome. Leuk Lymphoma 1999; 33: 601-605.
12. Kinney MC, Higgins RA, Medina EA. Anaplastic Large Cell Lymphoma. Twenty-Five Years of Discovery. Arch Pathol Lab Med 2011; 135: 19-43.
13. Thuilliez C, Watrelot-Virieux D, Chanut F, et al. Presumed primary muscular lymphoma in a dog. J Vet Diagn Invest 2008; 20: 824-826.
14. Hochberg J, Waxman IM, Kelly KM, et al. Adolescent non-Hodgkin lymphoma and Hodgkin lymphoma: state of science. Br J Haematol 2008; 144: 24-40.
15. Lim CY, Ong KO. Imaging of musculoskeletal lymphoma. Cancer Imaging 2013; 13: 448457.
16. Chew FS, Schellingerhout D, Keel SB. Primary lymphoma of skeletal muscle. AJR 1999; 172: 1370.
17. Driss M, Abbes I, Mrad K, et al. Primary CD30/ALK-1 positive anaplastic large cell lymphoma of the skeletal muscle in
18. a child. Pathologica 2009; 101: 97-100.
19. Kounami S, Shibuta K, Yoshiyama M, et al. Primary anaplastic large cell lymphoma of the psoas muscle: A case report and literature review. Acta Haematol 2012; 127: 186-188.
20. Kubo Y, Aoi J, Takamitsu J, et al. A case of anaplastic large cell lymphoma of skeletal muscle. J Dermatol 2014; 41: 999-1002.
21. Liao WP, Dai MS, Hsu LF. Anaplastic large-cell lymphoma primarily infiltrating femoral muscles. Ann Hematol 2005, 84: 764-766.
22. Recavarren RA, Yang J. Cytomorphologic features of primary anaplastic large cell lymphoma of the psoas muscle: A case report and literature review. Diagn Cytopathol 2009; 38: 208-212.
23. Akuzawa N, Hatori T, Takase A, et al. Malignant lymphoma in the psoas major muscle. Case Rep Hematol 2017; Article ID 3902748.
24. Alekshun TJ, Rezania D, Ayala E, et al. Skeletal muscle peripheral Tcell lymphoma. J Clin Oncol 2008; 26: 501503.
25. Binici DNR, Karaman A, Timur O, et al. Primary skeletal muscle lymphoma: A case report. Mol Clin Oncol 2018; 8: 80-82.
26. Bourdeanu L, Menon R, Somlo G. Diffuse large B cell lymphoma with calf muscle localization. Case Rep Hematol 2011; 2011, Article ID 292494.
27. Bozzola C, Boldrini R, Ramponi A, et al. Fine needle aspiration cytology in the diagnosis of nonHodgkin’s lymphomas of the muscle: A report of 2 cases. Acta Cytol 2005; 49: 213218.
28. Ceysens C, Horvath M, Termote JL, et al. Extranodal non-Hodgkin lymphoma of the head and neck presenting as a mandibular swelling: report of two cases. J Belge Radiol 1992; 75: 37-39.
29. Chim CS, Loong F, Ooi GC, et al. Primary skeletal muscle lymphoma. Am J Med 2002; 112: 79-80.
30. De Giorgi S, Piazzolla A, De Giorgi G, et al. Non Hodgkin’s lymphoma in the gluteal region: a case report. Chir Organi Mov 2004; 89: 329-338.
31. Derenzini E, Casadei B, Pellegrini C, et al. Non-Hodgkin lymphomas presenting as soft tissue masses: a single center experience and meta-analysis of the published series. Clin Lymphoma Myeloma Leuk 2013; 13: 258-265.
32. Eustace S, Winalski CS, McGowen A, et al. Skeletal muscle lymphoma: observations at MR imaging. Skeletal Radiol 1996; 25: 425-430.
33. Gao YH, Xu Q, Wei G, et al. Primary giant lymphoma of the right thigh: a case report and brief review of the literature. Oncol Lett 2012; 4: 1023-1026.
34. Grunshaw ND, Chalmers AG. Skeletal muscle lymphoma. Clin Radiol 1992; 45: 399-400.
35. Keung YK, Liang R. Report of a case of primary skeletal muscle lymphoma and review of the literature. Acta Haematol 1996; 96: 184-186.
36. Senthil Kumar K, Anantharamakrishnan R, Karunanithi R. T-cell lymphoma arising from gluteal muscle – a rare presentation. Chettinad Health City Med J 2013; 2: 1.
37. Laffosse JM, Brouchet AG, Molinier F, et al. A case of malignant primary non-Hodgkin’s lymphoma in skeletal muscle treated by exclusive chemotherapy. Joint Bone Spine 2009; 76: 86-88.
38. Majdoul S, Omari N, Allali Y, et al. Lymphome non Hodgkinien intramusculaire primitif chez le sujet jeune: à propos d’un cas et revue de la littérature. Pan Afr Med J 2016; 25: 223.
39. Matikas A, Oikonomopoulou D, Tzannou I, et al. Primary abdominal muscle lymphoma. BMJ Case Reports 2013; 2013:bcr2012008311.
40. Metzler JP, Fleckenstein JL, Vuitch F, et al. Skeletal muscle lymphoma: MRI evaluation. Magn Reson Imaging 1992; 10: 491-494.
41. Ozturk M, Cinka H, Veysel Polat A, et al. Primary muscle lymphoma in an elderly patient: Ultrasound and magnetic resonance imaging findings. Am J Diagn Imag 2019; 5: 1-3.
42. Panicek DM, Lautin JL, Schwartz LH, et al. Non-Hodgkin lymphoma in skeletal muscle manifesting as homogeneous masses with CT attenuation similar to muscle. Skeletal Radiol 1997; 26: 633-635.
43. Samuel LM, White J, Lessells AM, et al. Primary non-Hodgkins lymphoma of muscle. Clin Oncol 1999; 11: 49-51.
44. Set PAK, Somers JM, Britton PD, et al.Pictorial review; benign and malignant enlargement of the pterygo-masseteric muscle complex. Clin Radiol 1993; 48: 57-60.
Copyright: © 2021 Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Quick links
© 2021 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe