1. Perrem L, Gaietto K, Weiner DJ, et al. Advances in Pediatric Lung Function Testing Techniques. Clin Chest Med 2024; 45(3): 543–553.
2.
Stanojevic S, Bowerman C, Robinson P. Multiple breath washout: measuring early manifestations of lung pathology. Breathe (Sheff) 2021; 17(3): 210016.
3.
Burgel PR, Southern KW, Addy C, et al. Standards for the care of people with cystic fibrosis (CF); recognising and addressing CF health issues. J Cyst Fibros 2024; 23(2): 187–202.
4.
Bayfield KJ, Douglas TA, Rosenow T, et al. Time to get serious about the detection and monitoring of early lung disease in cystic fibrosis. Thorax 2021; 76(12): 1255–1265.
5.
Frauchiger BS, Binggeli S, Yammine S, et al. Longitudinal course of clinical lung clearance index in children with cystic fibrosis. Eur Respir J 2020; 58(1): 2002686.
6.
Schulzke SM, Frey U. Consensus statement on inert gas washout measurement: at the threshold of clinical use. Eur Respir J 2013; 41(3): 500–502.
7.
Subbarao P, Milla C, Aurora P, et al. Multiple-Breath Washout as a Lung Function Test in Cystic Fibrosis. A Cystic Fibrosis Foundation Workshop Report. Ann Am Thorac Soc 2015; 12(6): 932–939.
8.
Ramsey KA, Stanojevic S, Chavez L, et al. ERS technical standard: Global Lung Function Initiative reference values for multiple breath washout indices. Eur Respir J 2024; 64(6): 2400524.
9.
Bhakta NR, McGowan A, Ramsey KA, et al. European Respiratory Society/American Thoracic Society technical statement: standardisation of the measurement of lung volumes, 2023 update. Eur Respir J 2023; 62(4): 2201519.
10.
Gouveia Belinelo P, de, Nielsen A, Goddard B, et al. Clinical and lung function outcomes in a cohort of children with severe asthma. BMC Pulm Med 2020; 20(1): 66.
11.
Bell AS, Lawrence PJ, Singh D, et al. Feasibility and challenges of using multiple breath washout in COPD. Int J Chron Obstruct Pulmon Dis 2018; 13: 2113–2119.
12.
Ratjen F, Davis SD, Stanojevic S, et al. Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Respir Med 2019; 7(9): 802–809.
13.
Ratjen F, Hug C, Marigowda G, et al. Efficacy and safety of lumacaftor and ivacaftor in patients aged 6–11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled phase 3 trial. Lancet Respir Med 2017; 5(7): 557–567.
14.
Oude Engberink E, Ratjen F, Davis SD, et al. Inter-test reproducibility of the lung clearance index measured by multiple breath washout. Eur Respir J 2017; 50(4): 1700433.
15.
Perrem L, Stanojevic S, Solomon M, et al. Evaluation of clinically relevant changes in the lung clearance index in children with cystic fibrosis and healthy controls. Thorax 2023; 78(4): 362–367.
16.
Walicka-Serzysko K, Postek M, Milczewska J, et al. Change in lung clearance index with microbiological status in children with cystic fibrosis. Pediatr Pulmonol 2019; 54(6): 729–736.
17.
Wojsyk-Banaszak I, Więckowska B, Stachowiak Z, et al. Predictive value of impulse oscillometry and multiple breath washout parameters in pediatric patients with cystic fibrosis pulmonary exacerbation. Pediatr Pulmonol 2022; 57(6): 1466–1474.
18.
Ellemunter H, Fuchs SI, Unsinn KM, et al. Sensitivity of Lung Clearance Index and chest computed tomography in early CF lung disease. Respir Med 2010; 104(12): 1834–1842.
19.
Wojsyk-Banaszak I, Więckowska B, Szczepankiewicz A, et al. MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis. J Clin Med 2023; 12(15): 5136.
20.
Svedberg M, Imberg H, Gustafsson PM, et al. Longitudinal lung clearance index and association with structural lung damage in children with cystic fibrosis. Thorax 2023; 78(2): 176–182.
21.
Walicka-Serzysko K, Postek M, Milczewska J, et al. Lung function deterioration in school children with cystic fibrosis. Pediatr Pulmonol 2020; 55(11): 3030–3038.
22.
Walicka-Serzysko K, Postek M, Borawska-Kowalczyk U, et al. Pulmonary Function Tests in the Evaluation of Early Lung Disease in Cystic Fibrosis. J Clin Med 2023; 12(14): 4735.
23.
Nyilas S, Schlegtendal A, Singer F, et al. Alternative inert gas washout outcomes in patients with primary ciliary dyskinesia. Eur Respir J 2017; 49(1): 1600466.
24.
Green K, Buchvald FF, Marthin JK, et al. Ventilation inhomogeneity in children with primary ciliary dyskinesia. Thorax 2012; 67(1): 49–53.
25.
Kobbernagel HE, Green K, Ring AM, et al. One-year evolution and variability in multiple-breath washout indices in children and young adults with primary ciliary dyskinesia. Eur Clin Respir J 2019; 6(1): 1591841.
26.
Roehmel JF, Doerfler FJ, Koerner-Rettberg C, et al. Comparison of the Lung Clearance Index in Preschool Children with Primary Ciliary Dyskinesia and Cystic Fibrosis. Chest 2022; 162(3): 534–542.
27.
Singer F, Schlegtendal A, Nyilas S, et al. Lung clearance index predicts pulmonary exacerbations in individuals with primary ciliary dyskinesia: a multicentre cohort study. Thorax 2021; 76(7): 681–688.
28.
Nyilas S, Bauman G, Pusterla O, et al. Structural and Functional Lung Impairment in Primary Ciliary Dyskinesia. Assessment with Magnetic Resonance Imaging and Multiple Breath Washout in Comparison to Spirometry. Ann Am Thorac Soc 2018; 15(12): 1434–1442.
29.
Gustafsson PM. Peripheral airway involvement in CF and asthma compared by inert gas washout. Pediatr Pulmonol 2007; 42(2): 168–176.
30.
Keen C, Olin AC, Wennergren G, et al. Small airway function, exhaled NO and airway hyper-responsiveness in paediatric asthma. Respir Med 2011; 105(10): 1476–1484.
31.
Macleod KA, Horsley AR, Bell NJ, et al. Ventilation heterogeneity in children with well controlled asthma with normal spirometry indicates residual airways disease. Thorax 2009; 64(1): 33–37.
32.
Verbanck S, Schuermans D, Noppen M, et al. Evidence of acinar airway involvement in asthma. Am J Respir Crit Care Med 1999; 159(5 Pt 1): 1545–1550.
33.
Racette C, Lu Z, Kowalik K, et al. Lung clearance index is elevated in young children with symptom-controlled asthma. Health Sci Rep 2018; 1(8): e58.
34.
Vilmann L, Buchvald F, Green K, et al. Fractional exhaled nitric oxide and multiple breath nitrogen washout in preschool healthy and asthmatic children. Respir Med 2017; 133: 42–47.
35.
Sonnappa S, Bastardo CM, Wade A, et al. Symptom-pattern phenotype and pulmonary function in preschool wheezers. J Allergy Clin Immunol 2010; 126(3): 519–526.
36.
Steinbacher M, Pfleger A, Schwantzer G, et al. Small airway function before and after cold dry air challenge in pediatric asthma patients during remission. Pediatr Pulmonol 2017; 52(7): 873–879.
37.
Wawszczak M, Kulus M, Peradzyńska J. Peripheral airways involvement in children with asthma exacerbation. Clin Respir J 2022; 16(2): 97–104.
38.
Wawszczak M, Kulus M, Peradzyńska J. Diagnostic accuracy of peripheral lung function measurements in paediatric asthma control assessment: a pilot study. Postepy Dermatol Alergol 2023; 40(6): 772–778.
39.
Irving S, Fleming L, Ahmad F, et al. Lung clearance index and steroid response in pediatric severe asthma. Pediatr Pulmonol 2020; 55(4): 890–898.
40.
Arigliani M, Valentini E, Stocco C, et al. Regional ventilation inhomogeneity in survivors of extremely preterm birth. Pediatr Pulmonol 2020; 55(6): 1366–1374.
41.
Yammine S, Schmidt A, Sutter O, et al. Functional evidence for continued alveolarisation in former preterms at school age? Eur Respir J 2016; 47(1): 147–155.
42.
Walicka-Serzysko K, Postek M, Borawska-Kowalczyk U, et al. Long-term pulmonary outcomes of young adults born prematurely: a Polish prospective cohort study PREMATURITAS 20. BMC Pulm Med 2024; 24(1): 126.
43.
O’Neill K, Lakshmipathy GR, Neely C, et al. Multiple-Breath Washout Outcome Measures in Adults with Bronchiectasis. Ann Am Thorac Soc 2022; 19(9): 1489–1497.
44.
Rowan SA, Bradley JM, Bradbury I, et al. Lung clearance index is a repeatable and sensitive indicator of radiological changes in bronchiectasis. Am J Respir Crit Care Med 2014; 189(5): 586–592.
45.
Ring AM, Carlens J, Bush A, et al. Pulmonary function testing in children’s interstitial lung disease. Eur Respir Rev 2020; 29(157): 200019.
46.
Sisman Y, Buchvald F, Blyme AK, et al. Pulmonary function and fitness years after treatment for hypersensitivity pneumonitis during childhood. Pediatr Pulmonol 2016; 51(8): 830–837.
47.
Gur M, Yaacoby-Bianu K, Ilivitzki A, et al. Lung Clearance Index (LCI) in Patients with Bronchiolitis Obliterans: A Preliminary Report and Comparison to Cystic Fibrosis Patients. Lung 2016; 194(6): 1007–1013.
48.
Marczak H, Peradzyńska J, Lange J, et al. Pulmonary function in children with persistent tachypnea of infancy. Pediatr Pulmonol 2023; 58(1): 81–87.
49.
Arigliani M, Kirkham FJ, Sahota S, et al. Lung Clearance Index May Detect Early Peripheral Lung Disease in Sickle Cell Anemia. Ann Am Thorac Soc 2022; 19(9): 1507–1515.
50.
Streibel C, Willers CC, Bauman G, et al. Long-term pulmonary outcome of children with congenital diaphragmatic hernia: functional lung MRI using matrix-pencil decomposition enables side-specific assessment of lung function. Eur Radiol 2024; 34(6): 3773–3785.
51.
Driskel M, Horsley A, Fretwell L, et al. Lung clearance index in detection of post-transplant bronchiolitis obliterans syndrome. ERJ Open Res 2019; 5(4): 00164–2019.
52.
Rayment JH, Sandoval RA, Roden JP, et al. Multiple Breath Washout Testing to Identify Pulmonary Chronic Graft Versus Host Disease in Children After Hematopoietic Stem Cell Transplantation. Transplant Cell Ther 2022; 28(6): 328.e1–328.e7.
53.
Riley M, Arigliani M, Davies G, et al. Looking beyond LCI: Multiple breath washout phase III slope derived indices and their application in chronic respiratory disease in children. Pediatr Pulmonol 2024; 59(12): 3085–3094.
54.
Uhlving HH, Mathiesen S, Buchvald F, et al. Small airways dysfunction in long-term survivors of pediatric stem cell transplantation. Pediatr Pulmonol 2015; 50(7): 704–712.