Pulmonary granular cell tumor coexisting with
interstitial lung disease – a rare case report

Zeynep Sagnak Yilmaz; Safak Ersoz; Elif Ozsagır; Kubra Turker; Olcay Aycicek; Deha Ozturk

doi:10.5114/pjp.2025.158613

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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abstract:

Case report

Pulmonary granular cell tumor coexisting with interstitial lung disease – a rare case report

Zeynep Sagnak Yilmaz

¹

,

Safak Ersoz

¹

,

Elif Ozsagır

²

,

Kubra Ozturk Turker

³

,

Olcay Aycicek

⁴

,

Deha Cebi Ozturk

⁵

Department of Pathology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey
Department of Pathology, Bingol State Hospital, Bingol, Turkey
Department of Pathology, Kanuni Training and Research Hospital, Trabzon, Turkey
Department of Chest Diseases, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey
Department of Chest Diseases, Ahi Evren Chest Cardiovascular Surgery Training and Research Hospital, Trabzon, Turkey

Pol J Pathol 2025; 76 (4)

DOI: https://doi.org/10.5114/pjp.2025.158613

Online publish date: 2026/01/19

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A granular cell tumor (GCT) is a soft tissue neoplasm of rare occurrence in the lung. A 44-year-old male asphalt worker had interstitial lung disease. Incidentally, a 7 mm polypoid nodule was observed at the entrance of the right upper lobe bronchus. Tumor cells were characterized by a large granular eosinophilic cytoplasm and small, uniform nuclei. The neoplastic cells were diffuse positive for S-100, CD-68, NSE, vimentin, and SOX-10, and focal positive for calretinin and inhibin A. This case is unique in its distinction as the second literature case of pulmonary GCT coexisting with interstitial lung disease.

keywords:

Pulmonary granular cell tumor coexisting with interstitial lung disease – a rare case report

Zeynep Sagnak Yilmaz 1 , Safak Ersoz 1 , Elif Ozsagır 2 , Kubra Ozturk Turker 3 , Olcay Aycicek 4 , Deha Cebi Ozturk 5

granular cell tumor, interstitial lung disease, endobronchial tumor

Zeynep Sagnak Yilmaz

¹

,

Safak Ersoz

¹

,

Elif Ozsagır

²

,

Kubra Ozturk Turker

³

,

Olcay Aycicek

⁴

,

Deha Cebi Ozturk

⁵