eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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vol. 41
Original paper

Quality of life in adolescent and adult patients with persistent allergic rhinitis after one year of subcutaneous immunotherapy with a modified mite extract

Vanesa García-Paz
Laura Romero-Sánchez
Iván Carballeira-Anca
Carolina Gómez-Fariñas
Andrea Otero-Alonso
Soledad Sánchez-Sánchez
María González-Rivas
Leticia Vila-Sexto

  1. Allergy Department, Complexo Hospitalario Universitario de Ferrol, A Coruña, Spain
  2. Allergy Department, Complexo Hospitalario Universitario de Vigo, Pontevedra, Spain
  3. Allergy Department, Complexo Hospitalario Universitario de A Coruña, A Coruña, Spain
  4. Allergy Department, Complexo Hospitalario Universitario de Santiago de Compostela, A Coruña, Spain
  5. Paediatric Allergy Unit, Department of Paediatrics, Complexo Hospitalario Universitario A Coruña, A Coruña, Spain
Adv Dermatol Allergol 2024; XLI (3): 292-295
Online publish date: 2024/04/26
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Allergic rhinoconjunctivitis (AR) is an IgE-mediated inflammation of nasal and ocular mucosa after environmental allergen exposure, mainly by house dust mites (HDM). AR affects more than one third of the population worldwide and it is associated with loss of quality of life (QoL).

To analyse the improvement in the QoL in 50 patients with moderate-persistent AR due to house HDM before and after receiving 1 year of subcutaneous specific aeroallergen immunotherapy treatment (SAIT).

Material and methods:
A prospective observational study was performed based on clinical practice in 50 patients with moderate-severe persistent AR due to HDM and candidates to SAIT. Forty-one patients completed the study. Patients were evaluated with the ESPRINT short-version QoL questionnaire, a score of medication use and visual analogue scale (VAS) symptom score, prior to and 12 months after SAIT.

Forty-one patients (25 women, mean age 26.9 years). Mean ESPRINT values prior to the start SAIT was 3.06 (moderate-severe) and 1 year after starting subcutaneous SAIT the mean value dropped in all patients to 0.88 (mild). The VAS score symptom dropped from 8.26 to 3.68. 97.56% of patients used 3 or more drugs (oral antihistamine, ophthalmic/intranasal antihistamine, intranasal corticosteroid and/or oral antileukotrienes) prior to starting SAIT, and 1 year after it, 58.53% used one on-demand medication to control symptoms, oral antihistamine or nasal spray, and not daily use.

Subcutaneous SAIT seems to be a valid treatment in our patients with moderate-persistent AR due to HDM, since it reduces the ESPRINT score, VAS score and the use of medication. An improvement in the quality of life and satisfaction was observed by the patients themselves.


quality of life, allergic rhinoconjunctivitis, rhinitis, ESPRINT, VAS, children, adolescent, adult, treatment, immunotherapy

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