eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Editorial board Journal's reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
1/2021
vol. 59
 
Share:
Share:
more
 
 
abstract:
Case report

Rapid progression of an IDH-wild type histological low-grade glioma harbouring TERT promoter mutation and diffuse CD34 expression: a case report

Hongxiang Wang
1
,
Cong Tan
2
,
Tao Xu
1
,
Weiqing Li
3

1.
Department of Neurosurgery, Shanghai Changzheng Hospital, Shanghai, China
2.
Department of Pathology, Cancer Institute of Fudan University, Shanghai, China
3.
Department of Pathology, Shanghai Changzheng Hospital, Shanghai, China
Folia Neuropathol 2021; 59 (1): 104-111
Online publish date: 2021/03/31
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
IDH-wild type (WT) histological low-grade gliomas are a rare group with distinct character and prognostic heterogeneity. Studies involving genetic and molecular analyses are warranted to stratify these patients into specific entities for the facilitation of tumour management. In this study, we reported a novel IDH-WT glioma with histological characteristics of a low-grade tumour. Preoperative CT revealed massive calcification of this lesion and MRI showed a mixed hyperintense and hypointense signals on both T1- and T2-weighted images with a slight contrast enhancement. Micrography revealed dense deposits of calcium and diffuse microhaemorrhage in the tumour mass. Immunohistochemical staining showed diffuse expression of CD34 in neoplastic cells but uncertain positivity of glial fibrillary acidic protein (GFAP). Further sequencing found telomerase reverse transcriptase (TERT) promoter mutation in this tumour. Though the patient underwent surgical treatment followed by radiotherapy and temozolomide chemotherapy, the tumour recurred at the eight-month follow-up postoperatively. Taken together, extensive CD34 expression and TERT promoter mutation may empower the potential of malignant transformation to IDH-WT histological low-grade glioma to rapidly progress into glioblastoma.
keywords:

glioma, pre-GBM, IDH, CD34, TERT

Quick links
© 2021 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe