Advances in Dermatology and Allergology
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ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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6/2025
vol. 42
 
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Letter to the Editor

Refractory chronic spontaneous urticaria with markedly elevated eosinophilia and pigmentation: diagnostic antiparasitic therapy breaks the therapeutic impasse

Xuewei Huang
1
,
Xianjie Yang
1
,
Anqi Chen
1
,
Shifei Li
1
,
Zhiqiang Song
1
,
Qiquan Chen
1

  1. Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China
Adv Dermatol Allergol 2025; XLII (6): 621–624
DOI: https://doi.org/10.5114/ada.2025.157976
Online publish date: 2026/01/12
Article file
- Refractory chronic.pdf  [2.15 MB]
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1. Kolkhir P, Giménez-Arnau AM, Kulthanan K, et al. Urticaria. Nat Rev Dis Primers 2022; 8: 61.
2. Sabroe RA, Poon E, Orchard GE, et al. Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: comparison of patients with and without anti-FcepsilonRI or anti-IgE autoantibodies. J Allergy Clin Immunol 1999; 103: 484-93.
3. Kolkhir P, Church MK, Altrichter S, et al. Eosinopenia, in chronic spontaneous urticaria, is associated with high disease activity, autoimmunity, and poor response to treatment. J Allergy Clin Immunol Pract 2020; 8: 318-25.e5.
4. Giménez-Arnau AM, DeMontojoye L, Asero R, et al. The pathogenesis of chronic spontaneous urticaria: the role of infiltrating cells. J Allergy Clin Immunol Pract 2021; 9: 2195-208.
5. Altrichter S, Frischbutter S, Fok JS, et al. The role of eosinophils in chronic spontaneous urticaria. J Allergy Clin Immunol 2020; 145: 1510-6.
6. Tao Z, Zhu H, Zhang J, et al. Recent advances of eosinophils and its correlated diseases. Front Public Health 2022; 10: 954721.
7. Valent P, Klion AD, Roufosse F, et al. Proposed refined diagnostic criteria and classification of eosinophil disorders and related syndromes. Allergy 2023; 78: 47-59.
8. Balp MM, Halliday AC, Severin T, et al. Clinical remission of chronic spontaneous urticaria (CSU): a targeted literature review. Dermatol Ther 2022; 12: 15-27.
9. Kim NH, Lee AY. Histamine effect on melanocyte proliferation and vitiliginous keratinocyte survival. Exp Dermatol 2010; 19: 1073-9.
10. Minai-Fleminger Y, Elishmereni M, Vita F, et al. Ultrastructural evidence for human mast cell-eosinophil interactions in vitro. Cell Tissue Res 2010; 341: 405-15.
11. Gangwar RS, Friedman S, Seaf M, et al. Mast cells and eosinophils in allergy: close friends or just neighbors. Eur J Pharmacol 2016; 778: 77-83.
Copyright: © 2026 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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