eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
2/2022
vol. 39
 
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abstract:
Original paper

Relationship between vitamin D in obstructive sleep apnea syndrome and psoriasis patients

Hülya Albayrak
1
,
Nevin Fazlıoğlu
2
,
Bahadır Batar
3
,
Mehmet Emin Yanık
4
,
Mustafa Oran
5
,
Nejat Altıntaş
2

1.
Department of Dermatology, Namık Kemal University, Faculty of Medicine, Tekirdag, Turkey
2.
Department of Chest Diseases, Namık Kemal University, Faculty of Medicine, Tekirdag, Turkey
3.
Department of Medical Genetics, Namık Kemal University, Faculty of Medicine, Tekirdag, Turkey
4.
Department of Dermatology, Sancaktepe Region Hospital, Istanbul, Turkey
5.
Department of Internal Medicine, Namık Kemal University, Faculty of Medicine, Tekirdag, Turkey
Adv Dermatol Allergol 2022; XXXIX (2): 375-383
Online publish date: 2021/10/25
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Introduction
Although psoriasis and obstructive sleep apnea syndrome (OSAS) are associated with systemic inflammation, studies on their potential bilateral relationship are not sufficient.
Aim: To investigate vitamin D levels and receptor gene polymorphisms in patients with OSAS and psoriasis and the associations with these diseases.

Material and methods
One hundred thirty-seven patients included in the study consisted of 4 different groups: group 1, those with both diseases; group 2, those with OSAS only; group 3, patients with psoriasis only; and group 4, healthy controls. The patients’ serum calcium, phosphorus, AHI, Epworth Sleepiness Scale, Psoriasis Area Severity Index, and VDR TagI, ApaI, BsmI polymorphisms were compared.

Results
Vitamin D levels of groups 1, 2 and 3 were found to be lower than in controls. There was no statistically significant correlation between VDR TagI, ApaI, BsmI gene polymorphisms of the groups. Vitamin D levels were significantly higher in patients with heterozygous ApaI genotype (A/C) compared to patients with normal (A/A) or homozygous mutant (C/C) genotype (p < 0.05). No relationship was determined between VDR TagI, ApaI, BsmI, and the other parameters.

Conclusions
In our study, 1,25(OH)2-vitamin D3 levels were significantly lower in all disease groups compared to the control group. Although there is no difference between the groups in terms of VDR gene polymorphism, we think that there may be a bidirectional relationship between these diseases based on the low vitamin D levels.

keywords:

psoriasis, obstructive sleep apnea syndrome, vitamin D, VDR polymorphism

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