Folia Neuropathologica
eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
Share:
Send email
Share:
Original paper

Relationship of early-onset sepsis and neonatal encephalopathy: early-onset sepsis can increase short-term adverse outcomes of neonatal encephalopathy

Li Yang
1
,
Shirui Zhu
2
,
Mei Xue
2
,
Jianping Zhang
2
,
Ling Li
2
,
Beibei Wang
2
,
Jun Zhang
3

  1. The Affiliated Hospital of Yangzhou University Medical College (Taizhou People’s Hospital)/Neonatology, China
  2. The Affiliated Taizhou People’s Hospital of Nanjing Medical University/Neonatology, China
  3. Department of Nuclear Medicine, Yangzhou University, Yangzhou, China
Folia Neuropathol 2026; 64 (1)
DOI: https://doi.org/10.5114/fn.2026.159243
Online publish date: 2026/02/12
Article file
- Relationship.pdf  [0.09 MB]
Get citation
 
PlumX metrics:
 
1. Andersen M, Pedersen MV, Andelius TC, Kyng KJ, Henriksen TB. Neurological outcome following newborn encephalopathy with and without perinatal infection: a systematic review. Front Pediatr 2021; 9: 787804.
2. Andorka C, Barta H, Sesztak T, Nyilas N, Kovacs K, Dunai L, Rudas G, Jermendy A, Szabo M, Szakmar E. The predictive value of MRI scores for neurodevelopmental outcome in infants with neonatal encephalopathy. Pediatr Res 2025; 97: 253-260.
3. Aslam S, Strickland T, Molloy EJ. Neonatal encephalopathy: need for recognition of multiple etiologies for optimal management. Front Pediatr 2019; 7: 142.
4. Bekele T, Merga H, Tesfaye T, Asefa H. Predictors of mortality among neonates hospitalized with neonatal sepsis: a case control study from southern Ethiopia. BMC Pediatr 2022; 22: 1-9.
5. Bishara N. The use of biomarkers for detection of early-and late-onset neonatal sepsis. In: Hematology, immunology and infectious disease: neonatology questions and controversies. Saunders 2012; 303-315.
6. Bruun TU, DesRoches CL, Wilson D, Chau V, Nakagawa T, Yamasaki M, Hasegawa S, Fukao T, Marshall C, Mercimek-Andrews S. Prospective cohort study for identification of underlying genetic causes in neonatal encephalopathy using whole-exome sequencing. Genet Med 2018; 20: 486-494.
7. Car KP, Nakwa F, Solomon F, Velaphi SC, Tann CJ, Izu A, Lala SG, Madhi SA, Dangor Z. The association between early-onset sepsis and neonatal encephalopathy. J Perinatol 2022; 42: 354-358.
8. Dahou M, Lehlimi M, Korchi Z, Chaini R, Badre A, Chemsi M, Habzi A. Early-onset neonatal sepsis: the challenges of management. Am J Pediatr 2024; 10: 34-40.
9. Deshmukh M, Mehta S, Patole S. Sepsis calculator for neonatal early onset sepsis – a systematic review and meta-analysis. J Matern Fetal Neonatal Med 2021; 34: 1832-1840.
10. Dhudasia MB, Benitz WE, Flannery DD, Christ L, Rub D, Remaschi G, Puopolo KM, Mukhopadhyay S. Diagnostic performance and patient outcomes with C-reactive protein use in early-onset sepsis evaluations. J Pediatr 2023; 256: 98-104.
11. Dumbuya JS, Li S, Liang L, Zeng Q. Paediatric sepsis-associated encephalopathy (SAE): a comprehensive review. Mol Med 2023; 29: 27.
12. Glass HC. Hypoxic-ischemic encephalopathy and other neonatal encephalopathies. Continuum (Minneap Minn) 2018; 24: 57-71.
13. Glass HC, Rowitch DH. The role of the neurointensive care nursery for neonatal encephalopathy. Clin Perinatol 2016; 43: 547-557.
14. Hakobyan M, Dijkman KP, Laroche S, Naulaers G, Rijken M, Steiner K, van Straaten HL, Swarte RM, Ter Horst HJ, Zecic A, Zonnenberg IA. Outcome of infants with therapeutic hypothermia after perinatal asphyxia and early-onset sepsis. Neonatology 2019; 115: 127-133.
15. Hassell KJ, Ezzati M, Alonso-Alconada D, Hausenloy DJ, Robertson NJ. New horizons for newborn brain protection: enhancing endogenous neuroprotection. Arch Dis Child Fetal Neonatal Ed. 2015; 100: F541-552.
16. Hincu MA, Zonda GI, Stanciu GD, Nemescu D, Paduraru L. Relevance of biomarkers currently in use or research for practical diagnosis approach of neonatal early-onset sepsis. Children 2020; 7: 309.
17. Jenster M, Bonifacio SL, Ruel T, Rogers EE, Tam EW, Partridge JC, Barkovich AJ, Ferriero DM, Glass HC. Maternal or neonatal infection: association with neonatal encephalopathy outcomes. Pediatr Res 2014; 76: 93-99.
18. Kuzniewicz MW, Puopolo KM, Fischer A, Walsh EM, Li S, Newman TB, Kipnis P, Escobar GJ. A quantitative, risk-based approach to the management of neonatal early-onset sepsis. JAMA Pediatr 2017; 171: 365-371.
19. Martinello K, Hart AR, Yap S, Mitra S, Robertson NJ. Management and investigation of neonatal encephalopathy: 2017 update. Arch Dis Child Fetal Neonatal Ed. 2017; 102: F346-358.
20. Nelson KB, Penn AA. Is infection a factor in neonatal encephalopathy? Arch Dis Child Fetal Neonatal Ed. 2015; 100: F8-10.
21. Odd D, Sabir H, Jones SA, Gale C, Chakkarapani E. Risk factors for infection and outcomes in infants with neonatal encephalopathy: a cohort study. Pediatr Res 2024; 96: 785-791.
22. O’Dea M, Sweetman D, Bonifacio SL, El-Dib M, Austin T, Molloy EJ. Management of multi organ dysfunction in neonatal encephalopathy. Front Pediatr 2020; 8: 239.
23. Polcwiartek LB, Smith PB, Benjamin DK, Zimmerman K, Love A, Tiu L, Murray S, Kang P, Ebbesen F, Hagstrøm S, Clark RH. Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016). J Perinatol 2021; 41: 157-163.
24. Parker SJ, Kuzniewicz M, Niki H, Wu YW. Antenatal and intrapartum risk factors for hypoxic-ischemic encephalopathy in a US birth cohort. J Pediatr 2018; 203: 163-169.
25. Quirke FA, Ariff S, Battin MR, Bernard C, Biesty L, Bloomfield FH, Daly M, Finucane E, Healy P, Haas DM, Kirkham JJ. COHESION: a core outcome set for the treatment of neonatal encephalopathy. Pediatr Res 2024; 95: 922-930.
26. Sabir H, Bonifacio SL, Gunn AJ, Thoresen M, Chalak LF, Guidelines NB, Publications Committee. Unanswered questions regarding therapeutic hypothermia for neonates with neonatal encephalopathy. Semin Fetal Neonatal Med 2021; 26: 101257.
27. Song P, Theodoratou E, Li X, Liu L, Chu Y, Black RE, Campbell H,
28. Rudan I, Chan KY. Causes of death in children younger than five years in China in 2015: an updated analysis. J Glob Health 2016; 6: 020802.
29. Starodubtseva NL, Kirtbaya AR, Balashova EN, Gryzunova AS, Ionov OV, Zubkov VV, Silachev DN. Recent advances in diagnostics of neonatal hypoxic ischemic encephalopathy. Bulletin of RSMU 2022; 5-16.
30. Tann CJ, Martinello KA, Sadoo S, Lawn JE, Seale AC, Vega-Poblete M, Russell NJ, Baker CJ, Bartlett L, Cutland C, Gravett MG, Ip M, Le Doare K, Madhi SA, Rubens CE, Saha SK, Schrag S, Sobanjo-Ter Meulen A, Vekemans J, Heath PT; GBS Neonatal Encephalopathy Investigator Group. Neonatal encephalopathy with group B streptococcal disease worldwide: systematic review, Investigator Group Datasets, and meta-analysis. Clin Infect Dis 2017; 65 (suppl_2): S173-S189.
31. Tann CJ, Nakakeeto M, Willey BA, Sewegaba M, Webb EL, Oke I, Mutuuza ED, Peebles D, Musoke M, Harris KA, Sebire NJ. Perinatal risk factors for neonatal encephalopathy: an unmatched case-control study. Arch Dis Child Fetal Neonatal Ed. 2018; 103: F250-F256.
32. Walsh BH, Neil J, Morey J, Yang E, Silvera MV, Inder TE, Ortinau C. The frequency and severity of magnetic resonance imaging abnormalities in infants with mild neonatal encephalopathy.
33. J Pediatr 2017; 187: 26-33.e1.
34. Wachtel EV, Verma S, Mally PV. Update on the current management of newborns with neonatal encephalopathy. Curr Probl Pediatr Adolesc Health Care 2019; 49: 100636.
35. Wang Z, Zhang P, Zhou W, Xia S, Zhou W, Zhou X, Cheng X, Shi Y, Lin Z, Song D, Cheng G. Neonatal hypoxic-ischemic encephalopathy diagnosis and treatment: a National Survey in China. BMC Pediatr 2021; 21: 261.
36. Wassink G, Harrison S, Dhillon S, Bennet L, Gunn AJ. Prognostic neurobiomarkers in neonatal encephalopathy. Dev Neurosci 2022; 44: 331-343.
37. Zhang Y, Lei Y, Jiang H, Li X, Feng H. Analysis of the correlation between the severity of neonatal hypoxic ischemic encephalopathy and multiple organ dysfunction. Am J Transl Res 2022; 14: 311-319.
Copyright: © 2026 Mossakowski Medical Research Centre Polish Academy of Sciences and the Polish Association of Neuropathologists. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
  
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2026 Termedia Sp. z o.o.
Developed by Termedia.