eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
3/2022
vol. 39
 
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abstract:
Review paper

Resveratrol as a factor preventing skin aging and affecting its regeneration

Kamil Leis
1
,
Karolina Pisanko
1
,
Arkadiusz Jundziłł
1
,
Ewelina Mazur
1
,
Kaja Męcińska-Jundziłł
2
,
Henryk Witmanowski
1

1.
Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
2.
Department of Dermatology and Venerology, Faculty of Medicine in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
Adv Dermatol Allergol 2022; XXXIX (3): 439-445
Online publish date: 2022/07/15
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Resveratrol, a compound belonging to polyphenols, besides its action on the cardiovascular system, affects also wound healing, regeneration, and photoaging of the skin. By interactions with numerous substances and pathways, e.g. MAPK, MAPKK, FOXO3, TGF or metalloproteinase 1, it protects the skin against the harmful effects of type B ultraviolet radiation, which is the main factor in the skin aging processes. It also enhances collagen synthesis by activating the oestrogen receptor and reduces wrinkles. In damaged tissues, it accelerates skin regeneration and healing by activating, among others, VEGF. Based on the review of the literature, there is no doubt that resveratrol has the potential to be used in cosmetology, dermatology and plastic surgery. It can be used as a compound of anti-aging products or as a topical treatment of scars and wounds. In the future this polyphenol might be applied in pharmacotherapy of many dermatoses.
keywords:

resveratrol, skin aging, skin regeneration, polyphenols

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