Retinal ganglion cells death in glaucoma
– mechanism and potential treatment. Part I.

Wojciech Rokicki; Mariola Dorecka; Wanda Romaniuk

eISSN: 2719-3209
ISSN: 0023-2157

Klinika Oczna / Acta Ophthalmologica Polonica

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3/2007
vol. 109

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abstract:

Review paper

Retinal ganglion cells death in glaucoma – mechanism and potential treatment. Part I.

Wojciech Rokicki

^{1, 2}

,

Mariola Dorecka

^{1, 2}

,

Wanda Romaniuk

^{1, 2}

Katedra i Oddział Klinicznego Chorób Oczu Śląskiej Akademii Medycznej w Katowicach
Wojewódzki Szpital Specjalistyczny nr 5 im. Św. Barbary

Klinika Oczna 2007, 109 (3): 349-352

Online publish date: 2007/09/27

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Glaucoma is a kind of optic neuropathy where selective retinal ganglion cell loss is the major hallmark. Frequently glaucoma is associated with elevated intraocular pressure, but this condition is neither necessary nor sufficient for onset and progression of the disease. The exact mechanism of ganglion cell death in glaucoma and fully effective treatment of glaucomatous neuropathy still remain unknown. This article is a review of the recent researches relevant to IOP independent risk factors, mechanisms of RGC death and modern potential therapeutic strategies in glaucoma.

Part one includes review of blood flow changes, neurotrophic factors deprivation and apoptotic dysregulation findings in glaucoma

keywords:

Retinal ganglion cells death in glaucoma – mechanism and potential treatment. Part I.

Wojciech Rokicki 1, 2 , Mariola Dorecka 1, 2 , Wanda Romaniuk 1, 2

glaucoma, retinal ganglion cell, neuroprotection, apoptosis

Wojciech Rokicki

^{1, 2}

,

Mariola Dorecka

^{1, 2}

,

Wanda Romaniuk

^{1, 2}