eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2010
vol. 35
 
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abstract:

Review paper
Antiangiogenic treatment in renal cell carcinoma

Krzysztof Pastewka
,
Marek Zawadzki
,
Marcin Rudziński

(Centr Eur J Immunol 2010; 35 (4): 249-251)
Online publish date: 2011/01/13
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Renal cell carcinoma (RCC) is the most lethal of all genitourinary tumors which standard and often curative treatment is based on radical nephrectomy or nephron sparing surgery. Since 2009 the treatment of metastatic and advanced RCC, following the cytoreductive surgery, has targeted antiangiogenic therapy combined with immunotherapy. The objective response rate to anti-angiogenic agents targeting VEGF, PDGF and thyrosine kinase inhibition like bevacizumab, sunitynib, sorafenib and others is almost twice higher than in previously used interferon and /or interleukin 2 immunotherapy. Future possibilities in stabilization of kidney cancer were discussed.
keywords:

renal cell carcinoma, angiogenesis, antiangiogenic therapy, immunotherapy

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