eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2009
vol. 34
 
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abstract:

Review paper
DNA and RNA oligonucleotides as a new class of drugs

Dorota Radomska-Leśniewska
,
Agata Hevelke
,
Ewa Jankowska-Steifer
,
Jacek Malejczyk

Centr Eur J Immunol 2009; 34 (4): 280-283
Online publish date: 2009/12/30
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Aptamers are short synthetic single-stranded DNA or RNA oligonucleotides forming unique 3-D conformation. They are able to bind and neutralize their target molecules with high specificity and affinity. Therefore, they may specifically interfere in vivo with some protein function and thus display drug-like properties. This paper provides a brief description of possible clinical application of aptamers arguing for their tremendous therapeutic possibilities.
keywords:

aptamer, DNA, RNA, cancer therapy, ocular diseases, viral diseases, circulations disorders

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