eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2009
vol. 34
 
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abstract:

Review paper
Immunonutrition and lipopolysaccharide – induced Toll-like receptor signaling

Robert Słotwiński
,
Sylwia M. Słotwińska
,
Barbara J. Bałan
,
Sylwia Kędziora

Centr Eur J Immunol 2009; 34 (2): 137-142
Online publish date: 2009/05/20
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Septic infections in malnourished surgical patients show the highest morbidity and mortality rate. The attempt to correct the postoperative immune and nutritional disorders by introducing immunomodulating nutrition is a promising way of improving outcome, but as yet little is known about the mechanisms of correcting postoperative extensive inflammatory response (SIRS) to a massive infection using this type of nutrition. A significant role in innate antibacterial and inflammatory response play Toll-like receptors that recognize PAMPs-pathogen-associated molecular patterns. In this paper special emphasis was put on clinical trials and the research result for TLR-dependent immune response, anti-bacterial/anti-inflammatory response applying immunonutrition with increased concentrations of glutamine and unsaturated fatty acids.
keywords:

immunonutrition, toll-like receptors, sepsis

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