Central European Journal of Immunology
eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2009
vol. 34
 
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abstract:

Review paper
Role of angiogenesis and angiogenic factors in colorectal cancer

Barbara J. Bałan
,
Robert Słotwiński
,
Ewa Skopińska-Różewska

Centr Eur J Immunol 2009; 34 (4): 254-260
Online publish date: 2009/12/30
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Colorectal cancer, the second most frequent cause of death worldwide, is due to genetic changes in gastrointestinal cells Carcinogenesis depends on/is promoted/induced/initiated by/activation of oncogenes or inactivation of tumour suppressor genes. Microscopic human cancers may remain dormant for lifetime Tumor progression depends on a cascade of events during which the non-angiogenic phenotype switches to the angiogenic one. The switch promotes immediate recruitment of new blood vessel and, ultimately, tumor development.
keywords:

colorectal cancer, angiogenesis, angiogenic factors, VEGF
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