Advances in Dermatology and Allergology
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Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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6/2025
vol. 42
 
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Original paper

Risk factors, clinical presentations, and common culprits in drug allergies: a case-control study from Türkiye

Selma Yeşilkaya
1

  1. Division of Immunology and Allergy, Samsun Training and Research Hospital, Samsun, Turkey
Adv Dermatol Allergol 2025; XLII (1): 579–584
Online publish date: 2026/01/12
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- Risk factors.pdf  [0.15 MB]
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1. Yan Z, Feng Z, Jiao Z, et al. The severity of adverse drug reactions and their influencing factors based on the ADR monitoring center of Henan Province. Sci Rep 2021; 11: 20402.
2. Johansson SG, Bieber T, Dahl R, et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol 2004; 113: 832-6.
3. Çelik G, Karakaya G, Öztürk A, et al. Drug allergy in tertiary care in Turkey: results of a national survey. The ADAPT study: adult drug allergy perception in Turkey. Allergol Immunopathol 2014; 42: 573-9.
4. Demoly P, Bousquet J. Drug allergy diagnosis work up. Allergy 2002; 57: 37-40.
5. Voelker DH, Gonzalez-Estrada A, Park MA. Female sex as a risk factor for penicillin drug allergy in the inpatient setting. Allergy Asthma Proc 2022; 43: 163-7.
6. Jagpal PK, Alshareef S, Marriott JF, et al. Characterization, epidemiology and risk factors of multiple drug allergy syndrome and multiple drug intolerance syndrome: a systematic review. Clin Transl Allergy 2022; 12: e12190.
7. Arikoglu T, Aslan G, Batmaz SB, et al. Diagnostic evaluation and risk factors for drug allergies in children: from clinical history to skin and challenge tests. Int J Clin Pharm 2015; 37: 583-91.
8. Gomes ER, Kuyucu S. Epidemiology and risk factors in drug hypersensitivity reactions. Curr Treat Options Allergy 2017; 4: 239-57.
9. Crüger A, Kaur-Knudsen D, Zachariae C, et al. Risk factors and mortality among patients with severe muco-cutaneous drug reactions. Dan Med J 2015; 62: A5122.
10. Yalcinkaya A, Cavalli M, Cederholm A, et al. No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines. npj Vaccines 2024; 9: 42.
11. Brockow K, Romano A, Blanca M, et al. General considerations for skin test procedures in the diagnosis of drug hypersensitivity. Allergy 2002; 57: 45-51.
12. Torres MJ, Blanca M, Fernandez J, et al. Diagnosis of immediate allergic reactions to beta-lactam antibiotics. Allergy 2003; 58: 961-72.
13. Aberer W, Bircher A, Romano A, et al. Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations. Allergy 2003; 58: 854-63.
14. Gamboa PM. The epidemiology of drug allergy-related consultations in Spanish Allergology services: Alergológica-2005. J Investig Allergol Clin Immunol 2009; 19 Suppl 2: 45-50.
15. Yalcinkaya A, Yalcinkaya R, Sardh F, et al. Immune dynamics throughout life in relation to sex hormones and perspectives gained from gender-affirming hormone therapy. Front Immunol 2025; 15: 1501364.
16. Bouvy JC, De Bruin ML, Koopmanschap MA. Epidemiology of adverse drug reactions in Europe: a review of recent observational studies. Drug Saf 2015; 38: 437-53.
17. Rubio M, Bousquet PJ, Gomes E, et al. Results of drug hypersensitivity evaluations in a large group of children and adults. Clin Exp Allergy 2012; 42: 123-30.
18. Al-Ahmad M, Edin J, Musa F, et al. Drug allergy profile from a national drug allergy registry. Front Pharmacol 2021; 11: 555666.
19. Omer HM, Hodson J, Thomas SK, et al. Multiple drug intolerance syndrome: a large-scale retrospective study. Drug Safety 2014; 37: 1037-45.
20. Gomes ER, Demoly P. Epidemiology of hypersensitivity drug reactions. Curr Opin Allergy Clin Immunol 2005; 5: 309-16.
21. de Castro ED, Pinhão S, Paredes S, et al. Obesity markers in patients with drug allergy and body fat as a predictor. Ann Allergy Asthma Immunol 2021; 127: 100-8.
22. Dias de Castro E, Paredes S, Pinhão S, et al. Dietary parameters in patients with drug allergy: assessing dietary inflammatory index. PLoS One 2022; 17: e0277046.
23. Macy E, Ho NJ. Multiple drug intolerance syndrome: prevalence, clinical characteristics, and management. Ann Allergy Asthma Immunol 2012; 108: 88-93.
24. Schneck J, Fagot JP, Sekula P, et al. Effects of treatments on the mortality of Stevens-Johnson syndrome and toxic epidermal necrolysis: a retrospective study on patients included in the prospective EuroSCAR Study. J Am Acad Dermatol 2008; 58: 33-40.
25. Pichler WJ. Delayed drug hypersensitivity reactions. Ann Intern Med 2003; 139: 683-93.
26. Thong BYH, Tan TC. Epidemiology and risk factors for drug allergy. Br J Clin Pharmacol 2011; 71: 684-700.
27. Zhou L, Dhopeshwarkar N, Blumenthal KG, et al. Drug allergies documented in electronic health records of a large healthcare system. Allergy 2016; 71: 1305-13.
28. Warrington R, Silviu-Dan F, Wong T. Drug allergy. Allergy Asthma Clin Immunol 2018; 14 (Suppl 2): 60.
29. Blumenthal KG, Li Y, Acker WW, et al. Multiple drug intolerance syndrome and multiple drug allergy syndrome: epidemiology and associations with anxiety and depression. Allergy 2018; 73: 2012-23.
30. Yang CY, Chen CH, Deng ST, et al. Allopurinol use and risk of fatal hypersensitivity reactions: a nationwide population-based study in Taiwan. JAMA Intern Med 2015; 175: 1550-7.
31. Haddi E, Charpin D, Tafforeau M, et al. Atopy and systemic reactions to drugs. Allergy 1990; 45: 236-9.
32. Mirakian R, Ewan PW, Durham SR, et al. BSACI guidelines for the management of drug allergy. Clin Exp Allergy 2009; 39: 43-61.
33. Cornejo-Garcia J, Guéant-Rodriguez RM, Torres M, et al. Biological and genetic determinants of atopy are predictors of immediate-type allergy to betalactams, in S pain. Allergy 2012; 67: 1181-5.
34. Sánchez-Borges M, Caballero-Fonseca F, Capriles-Hulett A. Cofactors and comorbidities in patients with aspirin/NSAID hypersensitivity. Allergol Immunopathol (Madr) 2017; 45: 573-8.
35. Roehmel JF, Schwarz C, Mehl A, et al. Hypersensitivity to antibiotics in patients with cystic fibrosis. J Cyst Fibros 2014; 13: 205-11.
36. Phillips E, Mallal S. Drug hypersensitivity in HIV. Curr Opin Allergy Clin Immunol 2007; 7: 324-30.
37. Shiohara T, Kano Y. A complex interaction between drug allergy and viral infection. Clin Rev Allergy Immunol 2007; 33: 124-33.
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