eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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SCImago Journal & Country Rank
4/2018
vol. 69
 
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abstract:
Original paper

Steatosis influences hepatocytes proliferative potential in chronic hepatitis C patients

Andrzej Gabriel, Michał Kukla, Brygida Adamek, Kamil Tabor, Grzegorz Banasik, Maciej Horyniecki, Waldemar Halota

Pol J Pat hol 2018; 69 (4): 388-394
Online publish date: 2019/01/31
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The study evaluates the influence of steatosis on hepatocytes proliferative potential, reflected by proliferating cell nuclear antigen (PCNA) expression in chronic hepatitis C (CHC) patients both in steatotic and non-steatotic areas of lobules. The liver histology was evaluated according to Kleiner’s score. Nonalcoholic steatohepatitis (NASH) was also defined as the presence of lobular inflammation, hepatocyte ballooning and steatosis. Expression of PCNA was significantly in patients with definite NASH compared to those with simple steatosis, but not to those with borderline NASH. Advanced steatosis negatively influenced PCNA expression. NASH not only affects PCNA expression in staetotic, but also in non-steatotic lobule areas.

Expression of PCNA could be an independent indicator of changes in hepatocyte metabolism in CHC patients. High NAS values and low PCNA expression may be a negative prognostic factor in predicting the further course of the disease.
keywords:

chronic hepatitis C, PCNA, nonalcoholic fatty liver disease, steatosis, hepatocyte ballooning

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