Technical aspects and current clinical applications of the skin and skeletal muscle biopsy in neurological diagnostics: an overview

Dorota Dziewulska; Biruta Kierdaszuk; Paweł Gogol

doi:10.5114/fn.2022.119980

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2022
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abstract:

Review paper

Technical aspects and current clinical applications of the skin and skeletal muscle biopsy in neurological diagnostics: an overview

Dorota Dziewulska

¹

,

Biruta Kierdaszuk

¹

,

Paweł Gogol

²

Department of Neurology, Medical University of Warsaw, Warsaw, Poland

Department of Anaesthesiology and Intensive Care, Hospital of Our Lady of Perpetual Help, Wolomin, Poland

Folia Neuropathol 2022; 60 (3): 277-283

DOI: https://doi.org/10.5114/fn.2022.119980

Online publish date: 2022/11/03

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This short overview recalls the basic principles and technical aspects of skin and skeletal muscle biopsies in humans with paying special attention to the stages of these procedures essential for further correct morphological diagnosis. Some of these principles may also be useful in animal experimental studies. The authors emphasize the important role of proper thickness of the skin fragment, proper orientation of muscle fibres and a scalpel during skin biopsy, and proper concentration of fixatives. They recommend avoiding anaesthesia of the skeletal muscle itself and using forceps carefully so as not to crush the epidermis.

keywords:

Technical aspects and current clinical applications of the skin and skeletal muscle biopsy in neurological diagnostics: an overview

Dorota Dziewulska 1 , Biruta Kierdaszuk 1 , Paweł Gogol 2

muscle biopsy, skin biopsy, biopsy technique

Dorota Dziewulska

¹

,

Biruta Kierdaszuk

¹

,

Paweł Gogol

²