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2/2007
vol. 109 abstract:
Original paper
The assessment of the correlation between vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF-α), interleukin 6 (IL-6), glycaemic control (HbA1c) and the development of the diabetic retinopathy in children with diabetes mellitus type 1
Małgorzata Myśliwiec
1
,
Anna Balcerska
1
,
Katarzyna Zorena
2
,
Jolanta Myśliwska
2
,
Paweł Lipowski
3
,
Krystyna Raczyńska
3
Klinika Oczna 2007, 109 (2): 150-154
Online publish date: 2007/06/12
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The aim of the work is to assess the correlation between HbA1c, VEGF, TNF-α, IL-6 and the development of diabetic retinopathy in children diagnosed with diabetes mellitus type 1. One hundred fourty nine children with long-standing diabetes mellitus type 1 were enrolled in the study. The patients were divided into two subgroups: children with retinopathy (Group 1; n=28) and children without retinopathy (Group 2, n=121). The control group consisted of 62 healthy children. All the examined children had VEGF, TNF-α and IL-6 measured in the blood serum using highly sensitive ELISA tests. Statistically significant higher blood serum levels of HbA1c, VEGF, TNF-α and IL-6 were found in the group 1 in comparison with the group 2. Children of the group 2 in relation to healthy controls showed statistically significant higher blood serum levels of VEGF, TNF-α and IL-6. Elevated levels of VEGF, TNF-α, IL-6, HbA1c in blood serum of children with diabetes mellitus type 1 detected before development of overt signs of diabetic retinopathy might indicate the possibility of the occurrence of changes in the eye shortly.
keywords:
Diabetes Mellitus type 1, retinopathy diabetica, VEGF, TNF-α, IL-6 |
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POLSKI
