eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
6/2018
vol. 35
 
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abstract:
Original paper

The correlation between serum E-selectin levels and soluble interleukin-2 receptors with relation to disease activity in localized scleroderma

Karolina Wodok-Wieczorek, Natalia Salwowska, Ewa Syguła, Aleksandra Wodok, Dominika Wcisło-Dziadecka, Katarzyna Bebenek, Beata Bergler-Czop, Ligia Brzezińska-Wcisło

Adv Dermatol Allergol 2018; XXXV (6): 614-619
Online publish date: 2018/08/13
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Introduction
Scleroderma is a chronic connective tissue disease resulting in fibrosis.

Aim
The aim of the study was to determine the connection between sE-selectin and sIL-2R and the severity of skin lesions in various subtypes of LoS. Evaluation of disease severity, the location of skin lesions, the duration of symptoms and disease activity were assessed in relation to the three different LoS subtypes in patients with localized scleroderma.

Material and Methods
The study included 42 patients with localized scleroderma and the control group consisted of 41 healthy subjects. All patients in the LoS study group had a confirmed diagnosis via skin biopsy and underwent serology testing for sE-selectin and sIL-2R concentrations by enzyme-linked immunosorbent assay (ELISA).

Results
Significantly higher levels of sE-selectin and sIL-2R were observed in the LoS study group when compared with the control group (p < 0.001). The analysis showed a result close to statistical significance (p = 0.058) between sE-selectin concentration during the time of active disease in the LoS study group. The highest concentrations of sE-selectin and sIL-2R were observed in patients with the generalized subtype of LoS. A positive, statistically significant, curvilinear relationship was shown amid the modified Localized Skin Severity Index (mLoSSI) and sE-selectin and sIL-2R concentrations in the LoS study group.

Conclusions
Concentrations of the circulating form of sE-selectin appear to be an adequate marker of the endothelial function, positively correlating with the severity of the disease. The proven correlation of sIL-2R concentrations with the severity of the disease indicates that it is a valuable prognostic factor for predicting the impending course of the disease.

keywords:

-selectin, interleukin-2 receptors, localized scleroderma, connective tissue disease

references:
Chung L, Lin J, Furst DE, Fiorentino D. Systemic and localized scleroderma. Clin Dermatol 2006; 24: 374-92.
Fett N, Werth VP. Update on morphea: part I. Epidemiology, clinical presentation, and pathogenesis. J Am Acad Dermatol 2011; 64: 217-28.
Dunne JV, van Eeden SF, Keen KJ. L-selectin and skin damage in systemic sclerosis. PLoS One 2012; 7: e44814.
Iversen LV, Ostergaard O, Ullman S, et al. Circulating microparticles and plasma levels of soluble e- and p-selectins in patients with systemic sclerosis. Scand J Rheumatol 2013; 42: 473-82.
Hasegawa M, Asano Y, Endo H, et al. Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study. PLoS One 2014; 9: e88150.
Tedder TF, Steeber DA, Chen A, Engel P. The selectins: vascular adhesion molecules. FASEB J 1995; 9: 866-73.
Church AC. Clinical advances in therapies targeting the interleukin-2 receptor. QJM 2003; 96: 91-102.
Lis-Święty A, Brzezińska-Wcisło L, Wcisło-Dziadecka D. Badanie stężenia rozpuszczalnego receptora interleukiny 2 w surowicy chorych na twardzinę układową przed leczeniem i po leczeniu immunosupresyjnym. Dermatol Klin 2006; 8: 165-9.
Zulian F, Vallongo C, Woo P, et al. Localized scleroderma in childhood is not just a skin disease. Arthritis Rheum 2005; 52: 2873-81.
Saxton-Daniels S, Jacobe HT. An evaluation of long-term outcomes in adults with pediatric-onset morphea. Arch Dermatol 2010; 146: 1044-5.
Arkachaisri T, Pino S. Localized scleroderma severity index and global assessments: a pilot study of outcome instruments. J Rheumatol 2008; 35: 650-7.
Arkachaisri T, Vilaiyuk S, Li S, et al. The Localized Scleroderma Skin Severity Index and Physician Global Assessment of Disease Activity: a work in progress toward development of localized scleroderma outcome measures. J Rheumatol 2009; 36: 2819-29.
Arkachaisri T, Vilaiyuk S, Torok KS, Medsger TA. Development and initial validation of the localized scleroderma skin damage index and physician global assessment of disease damage: a proof-of-concept study. Rheumatology 2010; 49: 373-81.
Lis-Święty A, Wcisło-Dziadecka D, Kulawik I. Badanie stężenia e-selektyny w surowicy u chorych z chorobą Raynauda i twardziną układową. Postep Derm Alergol 2005; 22: 250-4.
Dziankowska-Bartkowiak B, Żebrowska A, Erkiert-Polguj A, et al. Chosen selectins and integrins in systemic sclerosis skin lesions. Adv Dermatol Allergol 2007; 24: 256-62.
Yamane K, Ihn H, Kubo M, et al. Increased serum levels of soluble vascular cell adhesion molecule 1 and E-selectin in patients with localized scleroderma. J Am Acad Dermatol 2000; 42: 64-9.
Takehara K, Sato S. Localized scleroderma is an autoimmune disorder. Rheumatology 2005; 44: 274-9.
Hasegawa M, Asano Y, Endo H, et al. Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study. PLoS One 2014; 9: e88150.
Chora I, Guiducci S, Manetti M, et al. Vascular biomarkers and correlation with peripheral vasculopathy in systemic sclerosis. Autoimmun Rev 2015; 14: 314-22.
Kuryliszyn-Moskal A, Klimiuk PA, Sierakowski S. Soluble adhesion molecules (sVCAM-1, sE-selectin), vascular endothelial growth factor (VEGF) and endothelin-1 in patients with systemic sclerosis: relationship to organ systemic involvement. Clin Rheumatol 2005; 24: 111-6.
Valim V, Assis LS, Simões MF, et al. Correlation between serum E-selectin levels and panoramic nailfold capillaroscopy in systemic sclerosis. Braz J Med Biol Res 2004; 37: 1423-7.
Lis-Święty A. Badanie stężenia rozpuszczalnego receptora interleukiny 2 w surowicy u chorych z objawem Raynauda i twardziną układową. Dermatol Klin 2007; 94: 563-9.
Ihn H, Sato S, Fujimoto M. Clinical significance of serum levels of soluble interleukin-2 receptor in patients with localized scleroderma. Br J Dermatol 1996; 134: 843-7.
Uziel Y, Krafchik BR, Feldman B, et al. Serum levels of soluble interleukin-2 receptor. A marker of disease activity in localized scleroderma. Arthritis Rheum 1994; 37: 898-901.
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