eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2004
vol. 29
 
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abstract:

The effect of complex herbal remedy on the angiogenic activity of L-1 sarcoma cells, L-1 sarcoma tumour growth, and on the bacterial infection in mice

Janusz Bany
,
Ewa Skopińska-Różewska
,
Joanna Chorostowska-Wynimko
,
Ewa Rogala
,
Ewa Sommer
,
Danuta Zdanowska
,
Małgorzata Filewska
,
Henryk Skurzak

Centr Eur J Immunol 2004; 29 (1): 29-34
Online publish date: 2004/12/22
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The effect of herbal remedy (further named HR), a complex preparation consisting of three substances: Echinacea purpurea extract, Allium sativum extract, and cocoa, on the growth of L-1 sarcoma, tumour angiogenesis, VEGF tumour concentration and Pseudomonas aeruginosa infection in mice were studied.
A significant inhibitory effect of the remedy on tumour angiogenic activity using cutaneous angiogenesis test, and an inhibitory effect on L-1 sarcoma growth were observed. However, the concentration of VEGF was higher in tumours of mice treated with the remedy as compared to the control group.
It was found that P. aeruginosa infection intensity was significantly lower (after treatment with the remedy) than in the control group. The possible mechanisms of action of the preparation and perspectives of its use in human clinic are discussed.
keywords:

L-1 sarcoma, tumour angiogenesis, VEGF, Pseudomonas aeruginosa, mice, herbal remedy

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