eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank

4/2003
vol. 28
 
Share:
Share:
more
 
 
abstract:

The effect of taurine and its metabolites on the pathogenic functions of rheumatoid arthritis fibroblast-like synoviocytes

Ewa Kontny
,
Iwona Janicka
,
Janusz Marcinkiewicz
,
Magdalena Chorąży-Massalska
,
Weronika Rudnicka
,
Włodzimierz Maśliński

Centr Eur J Immunol 2003; 28 (4): 167-172
Online publish date: 2004/09/17
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Fibroblast-like synoviocytes (FLS) are thought to contribute to rheumatoid arthritis (RA) pathogenesis via several mechanisms, e.g. by secreting numerous pro-inflammatory cytokines or by COX-2-generated synthesis of prostaglandin E2 (PGE2), another pleiotropic mediator of inflammation. Moreover, synovial hyperplasia, the most characteristic feature of RA, is belived to be a consquence of intractable proliferation and partial resistance of FLS to apoptosis. We have previously reported taurine chloramine (Tau-Cl) to represent potent inhibitory compound counteracting in vitro these pathogenic function of RA FLS. Tau-Cl is a chlorinated derivative of a dominant free amino acid taurine (Tau), originates from activated neutrophils, and is further converted into sulphoacetaldehyde (SA). The effect of SA on RA FLS functions has not been estimated yet. Therefore, the aim of present study was to compare simultaneously the effect of Tau, Tau-Cl and SA on select cellular responses of FLS, using FLS isolated from the same RA patients. We have found that among tested compounds only Tau-Cl, but neither Tau nor SA, exerts inhibitory effect on RA FLS proliferation as well as on the synthesis of IL-6 and PGE2 by these cells.
keywords:

rheumatoid arthritis synoviocytes, taurine, taurine chloramine, sulphoacetaldehyde, inflammation

FEATURED PRODUCTS
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe