eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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6/2011
vol. 49
 
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abstract:
Original paper

The effects of synthetic immunostimulator polyoxidonium on methotrexate treatment in rats with adjuvant arthritis

Jozef Rovenský
,
Karol Švik
,
Stanislava Blažíèková
,
Mária Stanèíková

Reumatologia 2011; 49, 6: 411–418
Online publish date: 2011/12/28
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The purpose of this study was to evaluate the effect of polyoxidonium (POX) on prophylactic treatment of adjuvant arthritis (AA) with methotrexate (MTX) in rats. Groups of rats with AA were treated with methotrexate (1 mg/kg/week), polyoxidonium (0.1 mg/kg) or their combination for a period of 28 days from adjuvant application. Body mass, hind paw swelling, arthrogram scores and a level of serum albumin were measured as markers of inflammation and arthritis. Treatment with low doses of methotrexate significantly inhibited the markers of both inflammation and arthritis. Methotrexate and its combination with POX significantly increased body mass of arthritic rats. Polyoxidonium administered alone had no significant effect on the hind paw swelling and arthritic score. In combination with MTX, POX markedly potentiated the beneficial effects of MTX, which resulted in a more significant reduction of hind paw swelling and arthritic scores. The concentration of albumin in the serum of arthritic controls was significantly lower than in healthy controls. Both MTX alone and the combination treatment with MTX + POX significantly inhibited the decrease in serum albumin. Polyoxidonium increased the treatment efficacy of basal treatment of AA with MTX (Tables I–IV). In patients with rheumatoid arthritis this immunomodulator may prevent the secondary infections and restore impaired immunological homeostasis.
keywords:

polyoxidonium, methotrexate, adjuvant arthritis



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