The efficacy of Nigella sativa supplementation for asthma control: a meta-analysis of randomized controlled studies

Anqiang Han; Danqin Shi

doi:10.5114/ada.2020.93220

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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4/2021
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abstract:

Review paper

The efficacy of Nigella sativa supplementation for asthma control: a meta-analysis of randomized controlled studies

Anqiang Han

¹

,

Danqin Shi

²

Department of Respiratory, Tongliang District People Hospital, Chongqing, China

Department of Obstetrics, Hechuan District People Hospital, Chongqing, China

Adv Dermatol Allergol 2021; XXXVIII (4): 561–565

DOI: https://doi.org/10.5114/ada.2020.93220

Online publish date: 2020/02/24

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Introduction
The efficacy of Nigella sativa supplementation for asthma control remains controversial. We have conducted a systematic review and meta-analysis to explore the influence of Nigella sativa supplementation on asthma control.

Material and methods
We have searched PubMed, EMBASE, Web of science, EBSCO, and Cochrane library databases through June 2019 for randomized controlled trials (RCTs) assessing the efficacy of Nigella sativa supplementation for asthma control.

Results
Four RCTs are included in the meta-analysis. Overall, compared with the control group for asthma, Nigella sativa supplementation is associated with the increased ACT scores (SMD = 0.50; 95% CI: 0.11–0.88; p = 0.01), and FEV1 (SMD = 1.84; 95% CI: 0.07–3.60; p = 0.04), but demonstrates no obvious impact on PEF (SMD = 3.11; 95% CI: –1.30 to 7.52; p = 0.17), IL-4 (SMD = –0.31; 95% CI: –1.21 to 0.59; p = 0.50), or IFN-γ (SMD = 1.11; 95% CI: –0.44 to 2.67; p = 0.16).

Conclusions
Nigella sativa supplementation may provide additional benefits for the treatment of asthma.

keywords:

The efficacy of Nigella sativa supplementation for asthma control: a meta-analysis of randomized controlled studies

Anqiang Han 1 , Danqin Shi 2

Nigella sativa, asthma, asthma control test, randomized controlled trials

Anqiang Han

¹

,

Danqin Shi

²