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4/2006
vol. 108 abstract:
Original paper
The estimation of selected parameters in antioxidant system in red blood cells in ROP screening of premature infants
Monika Oziębło-Kupczyk
1
,
Alina Bakunowicz-Łazarczyk
1
,
Krystyna Dzienis
2
,
Elżbieta Skrzydlewska
3
,
Marek Szczepański
2
,
Ewa Waszkiewicz
3
Online publish date: 2006/12/21
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Purpose
To estimate correlation between concentration of antioxidant system parameters in red blood cells in premature infants and prevalence of ROP Material and methods We examined 16 premature infants with the average birth weight of 1071g and gestational age of 29.1 weeks. Supraoxide dismutase (SOD), reduced glutatione (GSH), and glutathione peroxidase (GSH-Px), were measured at day 1 (cord blood), 7-th and 14-th day after birth. Premature infants had ROP screening. The control group included 12 infants born at term. Results 8 premature infants had ROP. There were higher levels of SOD, GSH and GSH-Px in premature infants with and without ROP, than in control group. Premature infants with ROP had lowest levels of GSH. Conclusions The glutathione status of red blood cells as a oxidative stress index in premature infants might be a reliable parameter, facilitating the early recognition of patients in immediate danger of ROP development. keywords:
retinopathy of prematurity, antioxidants, oxidative stress |
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POLSKI
