eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank

3/2003
vol. 28
 
Share:
Share:
more
 
 
abstract:

The immunopotentiating effect of Listeriolysin O in the response against Leishmania major in BALB/c mice

Jawaher A. Al-Salem
,
Khaled S. Tabbara

Centr Eur J Immunol 2003; 28 (3): 119–125
Online publish date: 2004/04/29
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
The development of a Leishmania major protective Th1 response is dependent on IL-12 production. Susceptible BALB/c mice develop a Th2 response. We have previously demonstrated that coinfection with Listeria monocytogenes resulting in type 1 cytokine production (IL-12 and IFN-g), potentiated the response of BALB/c mice to L. major. We investigated here whether Listeriolysin O (LLO), essential for the development of a protective anti-listerial response, was also required to immunopotentiate the response against L. major. Coinfection with L. major and an LLO-producing (LLO+), but not an LLO-nonproducing (LLO–) L. monocytogenes strain, reduced lesion size and parasite load, and increased IFN-g production. Semi-purified LLO also potentiated the response as shown by the containment of parasites in the spleens in well-defined focal granulomas in contrast to controls where more mature disorganized diffuse granulomas with higher parasite loads and necrosis were commonly seen.
keywords:

Leishmania, Listeria, coinfection, Listeriolysin O, IFN-g, Th1 cells

FEATURED PRODUCTS
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe