The overview of adverse events following immunization among Udayana University Hospital staff after receiving MPOX vaccination

Cokorda Agung Wahyu Purnamasidhi; David Christopher Tjandra; Ledwin Wibisono; Cokorda Pratiwi; I G Divasta; Ni Parahita; Ida Ayu Sri Wijayanti; Dewa Wardhana; Brian Rachman; Saktivi Harkitasari

doi:10.5114/fmpcr.2025.156539

eISSN: 2449-8580
ISSN: 1734-3402

Family Medicine & Primary Care Review

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4/2025
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Original paper

The overview of adverse events following immunization among Udayana University Hospital staff after receiving MPOX vaccination

Cokorda Agung Wahyu Purnamasidhi

¹

,

David Christopher Tjandra

²

,

Ledwin Meikel Wibisono

²

,

Cokorda Agung Pratiwi

²

,

I G Mahapraja Divasta

²

,

Ni Kadek Fitria Parahita

,

Ida Ayu Sri Wijayanti

³

,

Dewa Putu Wisnu Wardhana

⁴

,

Brian Eka Rachman

⁵

,

Saktivi Harkitasari

⁶

Tropical and Infectious Diseases Division, Internal Medicine Department, Udayana University Hospital, Bali, Indonesia
Medical Faculty, Udayana University, Bali, Indonesia
Department of Neurology, Udayana University Hospital, Bali, Indonesia
Department of Neurosurgery, Udayana University Hospital, Bali, Indonesia
Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, Indonesia
Department of Neurology, Faculty of Medicine and Health Science, Warmadewa University, Bali, Indonesia

Family Medicine & Primary Care Review 2025; 27(4)

DOI: https://doi.org/10.5114/fmpcr.2025.156539

Online publish date: 2025/12/22

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AMA

Purnamasidhi C, Tjandra D, Wibisono LM, et al. The overview of adverse events following immunization among Udayana University Hospital staff after receiving MPOX vaccination. Family Medicine & Primary Care Review. 2025;27(4):451-456. doi:10.5114/fmpcr.2025.156539.

APA

Purnamasidhi, C., Tjandra, D., Wibisono, L. M., Pratiwi, C. A., Divasta, I. M.,  & Parahita, N. K. et al. (2025). The overview of adverse events following immunization among Udayana University Hospital staff after receiving MPOX vaccination. Family Medicine & Primary Care Review, 27(4), 451-456. https://doi.org/10.5114/fmpcr.2025.156539

Chicago

Purnamasidhi, Cokorda Agung Wahyu, David Christopher Tjandra, Ledwin M Wibisono, Cokorda A Pratiwi, I G M Divasta, Ni K Parahita,  and Ida Ayu Sri Wijayanti et al. 2025. "The overview of adverse events following immunization among Udayana University Hospital staff after receiving MPOX vaccination". Family Medicine & Primary Care Review 27 (4): 451-456. doi:10.5114/fmpcr.2025.156539.

Harvard

Purnamasidhi, C., Tjandra, D., Wibisono, L., Pratiwi, C., Divasta, I., Parahita, N., Wijayanti, I., Wardhana, D., Rachman, B.,  and Harkitasari, S. (2025). The overview of adverse events following immunization among Udayana University Hospital staff after receiving MPOX vaccination. Family Medicine & Primary Care Review, 27(4), pp.451-456. https://doi.org/10.5114/fmpcr.2025.156539

MLA

Purnamasidhi, Cokorda Agung Wahyu et al. "The overview of adverse events following immunization among Udayana University Hospital staff after receiving MPOX vaccination." Family Medicine & Primary Care Review, vol. 27, no. 4, 2025, pp. 451-456. doi:10.5114/fmpcr.2025.156539.

Vancouver

Purnamasidhi C, Tjandra D, Wibisono L, Pratiwi C, Divasta I, Parahita N et al. The overview of adverse events following immunization among Udayana University Hospital staff after receiving MPOX vaccination. Family Medicine & Primary Care Review. 2025;27(4):451-456. doi:10.5114/fmpcr.2025.156539.

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Background
Monkeypox is a zoonotic disease caused by an Orthopoxvirus genus virus. Since 2024, Mpox cases have been reported to have reached more than 100,000 worldwide. Adverse Events Following Immunization (AEFI) information after Mpox vaccination is still limited and requires further research.

Objectives
This study aims to describe the adverse events following immunization (AEFI) among Udayana University Hospital staff after receiving Mpox vaccination.

Material and methods
This was an observational, descriptive study with a cross-sectional approach conducted in November 2024 at Udayana University Hospital. A total of 47 health workers who had received two doses of Mpox vaccination were selected using total sampling. Data were collected via Google Forms and analyzed using SPSS v.25 (IBM).

Results
After the first dose, 55.3% people experienced AEFI, such as pain (42.5%), swelling (19.1%), and drowsiness (19.1%), with symptoms starting < 24 hours in 34.1% cases. Symptom improvement occurred < 24 hours in 8.5%, within 1 day in 19.1%, 2–3 days in 17%, and 4–7 days in 10.7%. With the second dose, 51.1% people experienced AEFI, such as pain (34.04%), swelling (14.8%), and drowsiness (12.7%), with symptoms appearing < 24 hours in 25.5% and within 1 day in 23.4%. Improvement from second-dose AEFI occurred within 2–3 days for 17%, within 1 day for 14.9%, within 4–7 days for 8.5%, and > 7 days for 4.3%.

Conclusions
The study confirms the safety of Mpox vaccination for health workers, with most AEFIs being mild to moderate, resolving within 24 hours to a week. Limitations include a small sample size, self-reported data, and the absence of a control group.

keywords:

The overview of adverse events following immunization among Udayana University Hospital staff after receiving MPOX vaccination

Cokorda Agung Wahyu Purnamasidhi 1 , David Christopher Tjandra 2 , Ledwin Meikel Wibisono 2 , Cokorda Agung Pratiwi 2 , I G Mahapraja Divasta 2 , Ni Kadek Fitria Parahita , Ida Ayu Sri Wijayanti 3 , Dewa Putu Wisnu Wardhana 4 , Brian Eka Rachman 5 , Saktivi Harkitasari 6

immunization, Smallpox Vaccine, healthcare workers, Indonesia